ID   CPNA5_CAEEL             Reviewed;         717 AA.
AC   Q09219; B0M0L5; B0M0L6; B0M0L7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Copine family protein 5;
GN   Name=cpna-5; Synonyms=tag-178; ORFNames=B0495.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=a;
CC         IsoId=Q09219-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q09219-2; Sequence=VSP_041565, VSP_041568;
CC       Name=c;
CC         IsoId=Q09219-3; Sequence=VSP_041566, VSP_041567;
CC   -!- SIMILARITY: Belongs to the copine family. {ECO:0000305}.
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DR   EMBL; FO080132; CCD61480.1; -; Genomic_DNA.
DR   EMBL; FO080132; CCD61481.1; -; Genomic_DNA.
DR   EMBL; FO080132; CCD61479.1; -; Genomic_DNA.
DR   PIR; H88216; H88216.
DR   RefSeq; NP_495622.2; NM_063221.4. [Q09219-1]
DR   RefSeq; NP_871897.2; NM_182097.4. [Q09219-2]
DR   RefSeq; NP_871898.2; NM_182098.4.
DR   AlphaFoldDB; Q09219; -.
DR   SMR; Q09219; -.
DR   STRING; 6239.B0495.10a; -.
DR   EPD; Q09219; -.
DR   PaxDb; Q09219; -.
DR   EnsemblMetazoa; B0495.10a.1; B0495.10a.1; WBGene00007044. [Q09219-1]
DR   EnsemblMetazoa; B0495.10b.1; B0495.10b.1; WBGene00007044. [Q09219-2]
DR   EnsemblMetazoa; B0495.10c.1; B0495.10c.1; WBGene00007044. [Q09219-3]
DR   GeneID; 174248; -.
DR   KEGG; cel:CELE_B0495.10; -.
DR   UCSC; B0495.10a; c. elegans.
DR   CTD; 174248; -.
DR   WormBase; B0495.10a; CE42047; WBGene00007044; cpna-5. [Q09219-1]
DR   WormBase; B0495.10b; CE33022; WBGene00007044; cpna-5. [Q09219-2]
DR   WormBase; B0495.10c; CE42048; WBGene00007044; cpna-5. [Q09219-3]
DR   eggNOG; KOG1327; Eukaryota.
DR   InParanoid; Q09219; -.
DR   OMA; LTTYAKM; -.
DR   OrthoDB; 1067545at2759; -.
DR   PhylomeDB; Q09219; -.
DR   PRO; PR:Q09219; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00007044; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR   GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR   CDD; cd04047; C2B_Copine; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR037768; C2B_Copine.
DR   InterPro; IPR045052; Copine.
DR   InterPro; IPR010734; Copine_C.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10857; PTHR10857; 1.
DR   Pfam; PF07002; Copine; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50004; C2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..717
FT                   /note="Copine family protein 5"
FT                   /id="PRO_0000065091"
FT   DOMAIN          193..318
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          377..567
FT                   /note="VWFA"
FT   VAR_SEQ         1..59
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041565"
FT   VAR_SEQ         653..661
FT                   /note="QYLDVEIMR -> RMSLNTVYY (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041566"
FT   VAR_SEQ         662..717
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041567"
FT   VAR_SEQ         695..717
FT                   /note="MKFPRVELSTLESSGGSTQDSSL -> VCFFFQIITPISEIPSS (in
FT                   isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041568"
SQ   SEQUENCE   717 AA;  81583 MW;  F441F90C78ACCA53 CRC64;
     MTNSAMALPP TRINRRRSTK ALHDFFSRPF TQRRSQSIAG VRVSPRISVT PSCTSSKHAM
     SNTIEISITI HDFATTETAT QITCELYDNE TECEDKWSKV GTSSPHRFSR NIVFTDKFSY
     QYVFEKTQLI KAVFSRCHDR DKPSSSSRDI LATSIFKVDE LIGSFGLQLR RQLEKNGNIA
     SALSGTQRVT DEYLGGIIVS AEMPEKEQPI VVQFHGKSLD RKDFLWDETA VFFRVFRLEE
     GKDDDSLVFL YESEALKNHS HPQWAEFRLD TQDAADNRNR LLEIWVMYKD VDGKEGYIGK
     FLTTYAKMKY GPGSDNVYSV INDVKKAQKK SYENSGKMEL VKFTDVSFYS FLDYIVSGTQ
     LHFEIGVDFS SPEPVHELDQ RRFDGELHMA IRAIGSIIRD YTPNRLFAAF GIGAKIPPTF
     HESNEFFLNF SMDPICRGLD GVMEAYRKTQ TMVTPLKESK LSPVINYVTR MSHRSGFRGL
     HYHVLALFTR GEVTDLKEIQ QALNSASDAP LSILIIGMGD FDFSSLQKLC SKRKDGRRDV
     VQFIHLKSLL NGAEAPWLNK SRIAETALRH VPQHMVQYMH NANIAAKPPI QVCRSPLFHS
     SSLIPDKPTE FDFDLANKRP SVGIEIPSLM PNLILPPDLS PRPRQDRRGS DTQYLDVEIM
     RGSLTVRVPE RCHSVLQTSR EQYQRRLKER GLARMKFPRV ELSTLESSGG STQDSSL