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CPNE6_HUMAN
ID   CPNE6_HUMAN             Reviewed;         557 AA.
AC   O95741; B2RAG6; B7Z1M3; D3DS55; F5GXN1; Q53HA6; Q8WVG1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 3.
DT   03-AUG-2022, entry version 182.
DE   RecName: Full=Copine-6 {ECO:0000305};
DE   AltName: Full=Copine VI {ECO:0000250|UniProtKB:Q99829, ECO:0000312|HGNC:HGNC:2319};
DE   AltName: Full=Neuronal-copine {ECO:0000303|PubMed:9645480};
DE            Short=N-copine {ECO:0000303|PubMed:9645480};
GN   Name=CPNE6 {ECO:0000312|HGNC:HGNC:2319};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=9645480; DOI=10.1016/s0014-5793(98)00497-9;
RA   Nakayama T., Yaoi T., Yasui M., Kuwajima G.;
RT   "N-copine: a novel two C2-domain-containing protein with neuronal activity-
RT   regulated expression.";
RL   FEBS Lett. 428:80-84(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   TISSUE SPECIFICITY.
RX   PubMed=10403379; DOI=10.1016/s0014-5793(99)00700-0;
RA   Nakayama T., Yaoi T., Kuwajima G., Yoshie O., Sakata T.;
RT   "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain
RT   protein family, with OS-9, the product of a gene frequently amplified in
RT   osteosarcoma.";
RL   FEBS Lett. 453:77-80(1999).
RN   [8]
RP   INTERACTION WITH NECAB1.
RX   PubMed=12044471; DOI=10.1016/s0306-4522(02)00063-5;
RA   Sugita S., Ho A., Suedhof T.C.;
RT   "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual
RT   domain structure and a restricted expression pattern.";
RL   Neuroscience 112:51-63(2002).
RN   [9]
RP   TISSUE SPECIFICITY.
RX   PubMed=12949241; DOI=10.1189/jlb.0203083;
RA   Cowland J.B., Carter D., Bjerregaard M.D., Johnsen A.H., Borregaard N.,
RA   Lollike K.;
RT   "Tissue expression of copines and isolation of copines I and III from the
RT   cytosol of human neutrophils.";
RL   J. Leukoc. Biol. 74:379-388(2003).
RN   [10]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=23999003; DOI=10.1016/j.jdermsci.2013.07.010;
RA   Yoo J.C., Lim T.Y., Park J.S., Hah Y.S., Park N., Hong S.G., Park J.Y.,
RA   Yoon T.J.;
RT   "SYT14L, especially its C2 domain, is involved in regulating melanocyte
RT   differentiation.";
RL   J. Dermatol. Sci. 72:246-251(2013).
CC   -!- FUNCTION: Calcium-dependent phospholipid-binding protein that plays a
CC       role in calcium-mediated intracellular processes. Binds phospholipid
CC       membranes in a calcium-dependent manner (By similarity). Plays a role
CC       in dendrite formation by melanocytes (PubMed:23999003).
CC       {ECO:0000250|UniProtKB:Q9Z140, ECO:0000269|PubMed:23999003}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};
CC   -!- SUBUNIT: Interacts (via second C2 domain) with OS9 (via C-terminus);
CC       this interaction occurs in a calcium-dependent manner in vitro (By
CC       similarity). May interact with NECAB1 (PubMed:12044471).
CC       {ECO:0000250|UniProtKB:Q9Z140, ECO:0000269|PubMed:12044471}.
CC   -!- INTERACTION:
CC       O95741; P50222: MEOX2; NbExp=3; IntAct=EBI-719005, EBI-748397;
CC       O95741-2; O95994: AGR2; NbExp=5; IntAct=EBI-13312079, EBI-712648;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z140}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q9Z140}. Endosome
CC       {ECO:0000250|UniProtKB:Q9Z140}. Cytoplasmic vesicle, clathrin-coated
CC       vesicle {ECO:0000250|UniProtKB:Q9Z140}. Perikaryon
CC       {ECO:0000250|UniProtKB:Q9Z140}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q9Z140}. Note=Mainly cytoplasmic in absence of
CC       calcium. Associated predominantly with membranes in presence of
CC       calcium. Translocates to the cell membrane in a calcium-dependent
CC       manner. Colocalized with transferrin in intracellular clathrin-coated
CC       membrane vesicles in a calcium-dependent manner.
CC       {ECO:0000250|UniProtKB:Q9Z140}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O95741-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O95741-2; Sequence=VSP_054806;
CC   -!- TISSUE SPECIFICITY: Widely expressed in the brain (PubMed:9645480,
CC       PubMed:10403379, PubMed:12949241). Expressed weakly in the kidney,
CC       liver and fetal heart (PubMed:12949241). Expressed in melanocytes
CC       (PubMed:23999003). {ECO:0000269|PubMed:10403379,
CC       ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:23999003,
CC       ECO:0000269|PubMed:9645480}.
CC   -!- DOMAIN: The C2 domain 1 binds phospholipids in a calcium-independent
CC       manner and is not necessary for calcium-mediated translocation and
CC       association to the plasma membrane. The C2 domain 2 binds phospholipids
CC       in a calcium-dependent manner and is necessary for calcium-mediated
CC       translocation and association to the plasma membrane. The linker region
CC       contributes to the calcium-dependent translocation and association to
CC       the plasma membrane. The VWFA domain is necessary for association with
CC       intracellular clathrin-coated vesicles in a calcium-dependent manner.
CC       {ECO:0000250|UniProtKB:Q9Z140}.
CC   -!- SIMILARITY: Belongs to the copine family. {ECO:0000305}.
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DR   EMBL; AB009288; BAA75899.1; -; mRNA.
DR   EMBL; AK222675; BAD96395.1; -; mRNA.
DR   EMBL; AK314182; BAG36863.1; -; mRNA.
DR   EMBL; AK293655; BAH11559.1; -; mRNA.
DR   EMBL; AL136295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471078; EAW66119.1; -; Genomic_DNA.
DR   EMBL; CH471078; EAW66120.1; -; Genomic_DNA.
DR   EMBL; BC018046; AAH18046.1; -; mRNA.
DR   CCDS; CCDS61413.1; -. [O95741-2]
DR   CCDS; CCDS9607.1; -. [O95741-1]
DR   RefSeq; NP_001267487.1; NM_001280558.1. [O95741-2]
DR   RefSeq; NP_006023.1; NM_006032.3. [O95741-1]
DR   RefSeq; XP_005268273.1; XM_005268216.1.
DR   AlphaFoldDB; O95741; -.
DR   SMR; O95741; -.
DR   BioGRID; 114763; 16.
DR   IntAct; O95741; 15.
DR   MINT; O95741; -.
DR   STRING; 9606.ENSP00000440077; -.
DR   iPTMnet; O95741; -.
DR   PhosphoSitePlus; O95741; -.
DR   BioMuta; CPNE6; -.
DR   EPD; O95741; -.
DR   jPOST; O95741; -.
DR   MassIVE; O95741; -.
DR   MaxQB; O95741; -.
DR   PaxDb; O95741; -.
DR   PeptideAtlas; O95741; -.
DR   PRIDE; O95741; -.
DR   ProteomicsDB; 24474; -.
DR   ProteomicsDB; 51017; -. [O95741-1]
DR   Antibodypedia; 22599; 169 antibodies from 26 providers.
DR   DNASU; 9362; -.
DR   Ensembl; ENST00000397016.6; ENSP00000380211.2; ENSG00000100884.10. [O95741-1]
DR   Ensembl; ENST00000537691.5; ENSP00000440077.1; ENSG00000100884.10. [O95741-2]
DR   Ensembl; ENST00000645359.1; ENSP00000494138.1; ENSG00000285221.1. [O95741-2]
DR   Ensembl; ENST00000647071.1; ENSP00000494513.1; ENSG00000285221.1. [O95741-1]
DR   Ensembl; ENST00000689861.1; ENSP00000510387.1; ENSG00000100884.10. [O95741-1]
DR   GeneID; 9362; -.
DR   KEGG; hsa:9362; -.
DR   MANE-Select; ENST00000689861.1; ENSP00000510387.1; NM_006032.4; NP_006023.1.
DR   UCSC; uc010tnv.4; human. [O95741-1]
DR   CTD; 9362; -.
DR   GeneCards; CPNE6; -.
DR   HGNC; HGNC:2319; CPNE6.
DR   HPA; ENSG00000100884; Tissue enhanced (brain, retina).
DR   MIM; 605688; gene.
DR   neXtProt; NX_O95741; -.
DR   OpenTargets; ENSG00000100884; -.
DR   PharmGKB; PA26836; -.
DR   VEuPathDB; HostDB:ENSG00000100884; -.
DR   eggNOG; KOG1327; Eukaryota.
DR   GeneTree; ENSGT00940000161567; -.
DR   HOGENOM; CLU_020452_4_0_1; -.
DR   InParanoid; O95741; -.
DR   OMA; PLRCPQG; -.
DR   OrthoDB; 1067545at2759; -.
DR   PhylomeDB; O95741; -.
DR   TreeFam; TF316419; -.
DR   PathwayCommons; O95741; -.
DR   Reactome; R-HSA-1483206; Glycerophospholipid biosynthesis.
DR   SignaLink; O95741; -.
DR   BioGRID-ORCS; 9362; 15 hits in 1067 CRISPR screens.
DR   GeneWiki; CPNE6; -.
DR   GenomeRNAi; 9362; -.
DR   Pharos; O95741; Tbio.
DR   PRO; PR:O95741; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; O95741; protein.
DR   Bgee; ENSG00000100884; Expressed in temporal lobe and 91 other tissues.
DR   ExpressionAtlas; O95741; baseline and differential.
DR   Genevisible; O95741; HS.
DR   GO; GO:0030424; C:axon; ISS:UniProtKB.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR   GO; GO:0001786; F:phosphatidylserine binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR   GO; GO:1903861; P:positive regulation of dendrite extension; IDA:UniProtKB.
DR   CDD; cd04047; C2B_Copine; 1.
DR   CDD; cd01459; vWA_copine_like; 1.
DR   Gene3D; 2.60.40.150; -; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037768; C2B_Copine.
DR   InterPro; IPR045052; Copine.
DR   InterPro; IPR010734; Copine_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10857; PTHR10857; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF07002; Copine; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF49562; SSF49562; 2.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Calcium; Cell membrane; Cell projection; Cytoplasm;
KW   Cytoplasmic vesicle; Differentiation; Endosome; Membrane; Metal-binding;
KW   Reference proteome; Repeat.
FT   CHAIN           1..557
FT                   /note="Copine-6"
FT                   /id="PRO_0000144845"
FT   DOMAIN          2..127
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          134..263
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          306..526
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          244..303
FT                   /note="Linker region"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Z140"
FT   BINDING         167
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         167
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         173
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         229
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         229
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         231
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         231
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   BINDING         237
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   VAR_SEQ         1
FT                   /note="M -> MAFKEHGKITSCCIPGPINSSRAGAGAGASGWSSKGVRARAREPERG
FT                   APDREPSDM (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_054806"
FT   CONFLICT        13
FT                   /note="P -> Q (in Ref. 6; AAH18046)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        87
FT                   /note="L -> V (in Ref. 6; AAH18046)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="N -> S (in Ref. 2; BAH11559)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="P -> H (in Ref. 3; BAD96395)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   557 AA;  61991 MW;  CA1ECA3560926FC2 CRC64;
     MSDPEMGWVP EPPTMTLGAS RVELRVSCHG LLDRDTLTKP HPCVLLKLYS DEQWVEVERT
     EVLRSCSSPV FSRVLALEYF FEEKQPLQFH VFDAEDGATS PRNDTFLGST ECTLGQIVSQ
     TKVTKPLLLK NGKTAGKSTI TIVAEEVSGT NDYVQLTFRA YKLDNKDLFS KSDPFMEIYK
     TNEDQSDQLV WRTEVVKNNL NPSWEPFRLS LHSLCSCDVH RPLKFLVYDY DSSGKHDFIG
     EFTSTFQEMQ EGTANPGQEM QWDCINPKYR DKKKNYKSSG TVVLAQCTVE KVHTFLDYIM
     GGCQISFTVA IDFTASNGDP RSSQSLHCLS PRQPNHYLQA LRAVGGICQD YDSDKRFPAF
     GFGARIPPNF EVSHDFAINF DPENPECEEI SGVIASYRRC LPQIQLYGPT NVAPIINRVA
     EPAQREQSTG QATKYSVLLV LTDGVVSDMA ETRTAIVRAS RLPMSIIIVG VGNADFSDMR
     LLDGDDGPLR CPRGVPAARD IVQFVPFRDF KDAAPSALAK CVLAEVPRQV VEYYASQGIS
     PGAPRPCTLA TTPSPSP
 
 
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