CPNE9_RAT
ID CPNE9_RAT Reviewed; 553 AA.
AC Q5BJS7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Copine-9 {ECO:0000305};
DE AltName: Full=Copine IX {ECO:0000312|RGD:1309212};
GN Name=Cpne9 {ECO:0000312|RGD:1309212};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable calcium-dependent phospholipid-binding protein that
CC may play a role in calcium-mediated intracellular processes. Plays a
CC role in dendrite formation by melanocytes.
CC {ECO:0000250|UniProtKB:Q8IYJ1, ECO:0000250|UniProtKB:Q99829}.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};
CC -!- SIMILARITY: Belongs to the copine family. {ECO:0000305}.
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DR EMBL; BC091347; AAH91347.1; -; mRNA.
DR RefSeq; NP_001020153.1; NM_001024982.1.
DR AlphaFoldDB; Q5BJS7; -.
DR SMR; Q5BJS7; -.
DR BioGRID; 255600; 1.
DR IntAct; Q5BJS7; 1.
DR MINT; Q5BJS7; -.
DR STRING; 10116.ENSRNOP00000059939; -.
DR iPTMnet; Q5BJS7; -.
DR PhosphoSitePlus; Q5BJS7; -.
DR jPOST; Q5BJS7; -.
DR PaxDb; Q5BJS7; -.
DR PRIDE; Q5BJS7; -.
DR Ensembl; ENSRNOT00000067396; ENSRNOP00000059939; ENSRNOG00000023077.
DR GeneID; 297516; -.
DR KEGG; rno:297516; -.
DR UCSC; RGD:1309212; rat.
DR CTD; 151835; -.
DR RGD; 1309212; Cpne9.
DR eggNOG; KOG1327; Eukaryota.
DR GeneTree; ENSGT00940000159659; -.
DR InParanoid; Q5BJS7; -.
DR OrthoDB; 1067545at2759; -.
DR PRO; PR:Q5BJS7; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000023077; Expressed in cerebellum and 8 other tissues.
DR ExpressionAtlas; Q5BJS7; baseline and differential.
DR Genevisible; Q5BJS7; RN.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR GO; GO:1903861; P:positive regulation of dendrite extension; ISO:RGD.
DR CDD; cd04047; C2B_Copine; 1.
DR CDD; cd01459; vWA_copine_like; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037768; C2B_Copine.
DR InterPro; IPR045052; Copine.
DR InterPro; IPR010734; Copine_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10857; PTHR10857; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF07002; Copine; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49562; SSF49562; 2.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Calcium; Differentiation; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..553
FT /note="Copine-9"
FT /id="PRO_0000277585"
FT DOMAIN 1..125
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 132..255
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 299..500
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 531..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..553
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 163
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 163
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 169
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 225
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 225
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 227
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 227
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 233
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
SQ SEQUENCE 553 AA; 61811 MW; D0FA7377F2D41E3E CRC64;
MSLGGASERS VPATKIEITV SCRNLLDLDT FSKSDPMVVL HTQSRASQEW REFGRTEVID
NTLNPDFVRK FVLDYFFEEK QNLRFDVYNV DSKANISKPK DFLGQAFLAL GEVIGGQGSR
VERPLTGVPG KKCGTILLTA EELSNCRDIA TMQLCANKLD KKDFFGKSDP FLVFYRSNED
GTFTICHKTE VVKNTLNPVW QPFSIPVRAL CNGDYDRTVK IDVYDWDRDG SHDFIGEFTT
SYRELSKAQN QFTVYEVLNP RKKCKKKKYT NSGTVTLLSF SVDSEFTFVD YIKGGTQLNF
TVAIDFTASN GNPLQPTSLH YMSPYQLSAY AMALKAVGEI IQDYDSDKLF PAYGFGAKLP
PEGRISHQFP LNNNDEDPNC AGIEGVLESY FQSLRTVQLY GPTYFAPVIN QVARAAAKIS
DGSQYYVLLI ITDGVISDMT QTKEAIVSAS SLPMSIIIVG VGPAMFEAME ELDGDDVRVS
SRGRYAERDI VQFVPFRDYV DRSGNQVLSM ARLAKDVLAE IPEQLLSYMR TRDIQPRPPP
PANPNPTSAP EQP
