ID   CPNF_DICDI              Reviewed;         550 AA.
AC   Q1ZXB3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Copine-F;
GN   Name=cpnF; ORFNames=DDB_G0291498;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=17259548; DOI=10.1128/ec.00322-06;
RA   Damer C.K., Bayeva M., Kim P.S., Ho L.K., Eberhardt E.S., Socec C.I.,
RA   Lee J.S., Bruce E.A., Goldman-Yassen A.E., Naliboff L.C.;
RT   "Copine A is required for cytokinesis, contractile vacuole function, and
RT   development in Dictyostelium.";
RL   Eukaryot. Cell 6:430-442(2007).
CC   -!- DEVELOPMENTAL STAGE: Expressed at relatively high levels in vegetative
CC       cells. The expression goes down until the 10th hour of development and
CC       then plateau until the 16th hour. {ECO:0000269|PubMed:17259548}.
CC   -!- SIMILARITY: Belongs to the copine family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000177; EAS66821.1; -; Genomic_DNA.
DR   RefSeq; XP_001134504.1; XM_001134504.1.
DR   AlphaFoldDB; Q1ZXB3; -.
DR   SMR; Q1ZXB3; -.
DR   STRING; 44689.DDB0233133; -.
DR   PaxDb; Q1ZXB3; -.
DR   EnsemblProtists; EAS66821; EAS66821; DDB_G0291498.
DR   GeneID; 8628206; -.
DR   KEGG; ddi:DDB_G0291498; -.
DR   dictyBase; DDB_G0291498; cpnF.
DR   eggNOG; KOG1327; Eukaryota.
DR   HOGENOM; CLU_030908_0_0_1; -.
DR   InParanoid; Q1ZXB3; -.
DR   OMA; CKTIKMY; -.
DR   PhylomeDB; Q1ZXB3; -.
DR   Reactome; R-DDI-1483206; Glycerophospholipid biosynthesis.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   PRO; PR:Q1ZXB3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR   GO; GO:0031090; C:organelle membrane; IDA:dictyBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR   GO; GO:0071277; P:cellular response to calcium ion; IBA:GO_Central.
DR   CDD; cd04047; C2B_Copine; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037768; C2B_Copine.
DR   InterPro; IPR045052; Copine.
DR   InterPro; IPR010734; Copine_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10857; PTHR10857; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF07002; Copine; 1.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..550
FT                   /note="Copine-F"
FT                   /id="PRO_0000330659"
FT   DOMAIN          1..115
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          123..246
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          296..521
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
SQ   SEQUENCE   550 AA;  62897 MW;  7EEE2A137A06F0E8 CRC64;
     MAETIRPISK IELRFKLADI KKPSSQIIVY CNSGDSKRFD LIGATERIDN KSEPFFNTTI
     NIDYYFESVQ KLYLLAINHN LKTLDFTKID QLDVVGEFTP TIGDLISRDG KRLIGDIKDK
     DKITGKIEIT AEEIYETGHN IILQLKGTKL DKKDLFSSDP YFKIYKSSPS GNSIVFESSV
     IKNNINPIFD PIVIRLQELN GGCMFRELTF EFWDHNDIVD DELIGSFRTN TDEILSGIIK
     EFPIINQKLK SKKSNYEHSG IINFIDSRIL YKPTIQDFIN GNGNGNGNGD GNCLIDLMVA
     IDCTESNGDQ KLETSLHYNV KPHQNQYIRS LLALESQLLN NFGVKLEKRV EVFGFGAVIN
     KHPNHNFRFH YIIDDRPNTL KAGISGVIEL YDKAIPKIQF TSPTKISSII EDATRYSLQD
     FHSTQLKYSI LLILIDSDIT DYESTVDEIV EASKAPLSII FIGVGEYSFQ NIPQLDGEKN
     GNIRLIGRFD RKQIRDNVHF ISFKEFSINQ IDFQNEILRK LPNQLTEFME FKNYLPNGLS
     YTQTEIKKIK