CPR3_CAEEL
ID CPR3_CAEEL Reviewed; 370 AA.
AC P43507; Q9TW93;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Cathepsin B-like cysteine proteinase 3;
DE EC=3.4.22.-;
DE AltName: Full=Cysteine protease-related 3;
DE Flags: Precursor;
GN Name=cpr-3; ORFNames=T10H4.12;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Bristol N2;
RX PubMed=8561899; DOI=10.1089/dna.1996.15.75;
RA Larminie C.G.C., Johnstone I.L.;
RT "Isolation and characterization of four developmentally regulated cathepsin
RT B-like cysteine protease genes from the nematode Caenorhabditis elegans.";
RL DNA Cell Biol. 15:75-82(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC ECO:0000255|PROSITE-ProRule:PRU10090}.
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DR EMBL; L39890; AAA98788.1; -; mRNA.
DR EMBL; L39925; AAA98782.1; -; Genomic_DNA.
DR EMBL; Z81119; CAB61032.2; -; Genomic_DNA.
DR EMBL; Z82057; CAB61032.2; JOINED; Genomic_DNA.
DR PIR; T37282; T37282.
DR RefSeq; NP_506790.1; NM_074389.3.
DR AlphaFoldDB; P43507; -.
DR SMR; P43507; -.
DR STRING; 6239.T10H4.12; -.
DR MEROPS; C01.A33; -.
DR EPD; P43507; -.
DR PaxDb; P43507; -.
DR PeptideAtlas; P43507; -.
DR EnsemblMetazoa; T10H4.12.1; T10H4.12.1; WBGene00000783.
DR GeneID; 180033; -.
DR KEGG; cel:CELE_T10H4.12; -.
DR UCSC; T10H4.12; c. elegans.
DR CTD; 180033; -.
DR WormBase; T10H4.12; CE27590; WBGene00000783; cpr-3.
DR eggNOG; KOG1543; Eukaryota.
DR HOGENOM; CLU_012184_3_3_1; -.
DR InParanoid; P43507; -.
DR OMA; DEKIPYW; -.
DR OrthoDB; 865289at2759; -.
DR PhylomeDB; P43507; -.
DR PRO; PR:P43507; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00000783; Expressed in adult organism and 2 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW Signal; Thiol protease; Zymogen.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT PROPEP 17..91
FT /evidence="ECO:0000255"
FT /id="PRO_0000026192"
FT CHAIN 92..370
FT /note="Cathepsin B-like cysteine proteinase 3"
FT /id="PRO_0000026193"
FT ACT_SITE 120
FT /evidence="ECO:0000250"
FT ACT_SITE 284
FT /evidence="ECO:0000250"
FT ACT_SITE 304
FT /evidence="ECO:0000250"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..134
FT /evidence="ECO:0000250"
FT DISULFID 117..162
FT /evidence="ECO:0000250"
FT DISULFID 153..210
FT /evidence="ECO:0000250"
FT DISULFID 154..158
FT /evidence="ECO:0000250"
FT DISULFID 190..214
FT /evidence="ECO:0000250"
FT DISULFID 198..202
FT /evidence="ECO:0000250"
SQ SEQUENCE 370 AA; 40770 MW; E6E50FF7C16F0867 CRC64;
MLKVYFLALF LAGCSAFVLD EIRGINIGQS PQKVLVDHVN TVQTSWVAEH NEISEFEMKF
KVMDVKFAEP LEKDSDVASE LFVRGEIVPE PLPDTFDARE KWPDCNTIKL IRNQATCGSC
WAFGAAEVIS DRVCIQSNGT QQPVISVEDI LSCCGTTCGY GCKGGYSIEA LRFWASSGAV
TGGDYGGHGC MPYSFAPCTK NCPESTTPSC KTTCQSSYKT EEYKKDKHYG ASAYKVTTTK
SVTEIQTEIY HYGPVEASYK VYEDFYHYKS GVYHYTSGKL VGGHAVKIIG WGVENGVDYW
LIANSWGTSF GEKGFFKIRR GTNECQIEGN VVAGIAKLGT HSETYEDDGG AATSCSFIMC
TLMVLTYYFV
