CPR5_ARATH
ID CPR5_ARATH Reviewed; 564 AA.
AC Q9LV85; Q8W3U8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein CPR-5 {ECO:0000303|PubMed:11846876};
DE AltName: Full=Protein constitutive expression of pathogenesis-related genes 5 {ECO:0000303|PubMed:11846876};
DE Short=Protein constitutive expression of PR genes 5 {ECO:0000303|PubMed:11846876};
DE AltName: Full=Protein hypersenescence-1 {ECO:0000303|PubMed:11846876};
GN Name=CPR5 {ECO:0000303|PubMed:11846876};
GN Synonyms=HYS1 {ECO:0000303|PubMed:11846876};
GN OrderedLocusNames=At5g64930 {ECO:0000312|Araport:AT5G64930};
GN ORFNames=MXK3.16 {ECO:0000312|EMBL:BAA97305.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS
RP OF PRO-535.
RC TISSUE=Leaf;
RX PubMed=11846876; DOI=10.1046/j.0960-7412.2001.01228.x;
RA Yoshida S., Ito M., Nishida I., Watanabe A.;
RT "Identification of a novel gene HYS1/CPR5 that has a repressive role in the
RT induction of leaf senescence and pathogen-defence responses in Arabidopsis
RT thaliana.";
RL Plant J. 29:427-437(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Anderson L.K., Bowling S.A., Boch J., Clarke J.D.V., Kunkel B.N., Dong X.;
RT "Cloning of CPR5 (constitutive expresser of pathogenesis related genes), a
RT novel regulator of disease resistance and senescence.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=9338960; DOI=10.2307/3870444;
RA Bowling S.A., Clarke J.D., Liu Y., Klessig D.F., Dong X.;
RT "The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-
RT independent resistance.";
RL Plant Cell 9:1573-1584(1997).
RN [6]
RP FUNCTION.
RA Boch J., Verbsky M.L., Robertson T.L., Larkin J.C., Kunkel B.N.;
RT "Analysis of resistance gene-mediated defense responses in Arabidopsis
RT thaliana plants carrying a mutation in CPR5.";
RL Mol. Plant Microbe Interact. 11:1196-1206(1998).
RN [7]
RP FUNCTION.
RX PubMed=11728314; DOI=10.1016/s0960-9822(01)00590-5;
RA Kirik V., Bouyer D., Schoebinger U., Bechtold N., Herzog M.,
RA Bonneville J.-M., Huelskamp M.;
RT "CPR5 is involved in cell proliferation and cell death control and encodes
RT a novel transmembrane protein.";
RL Curr. Biol. 11:1891-1895(2001).
RN [8]
RP SUBCELLULAR LOCATION, AND PROBABLE FUNCTION.
RX PubMed=21875893; DOI=10.1104/pp.111.179804;
RA Perazza D., Laporte F., Balague C., Chevalier F., Remo S., Bourge M.,
RA Larkin J., Herzog M., Vachon G.;
RT "GeBP/GPL transcription factors regulate a subset of CPR5-dependent
RT processes.";
RL Plant Physiol. 157:1232-1242(2011).
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH SIM AND SMR1.
RX PubMed=25455564; DOI=10.1016/j.chom.2014.10.005;
RA Wang S., Gu Y., Zebell S.G., Anderson L.K., Wang W., Mohan R., Dong X.;
RT "A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in
RT plant effector-triggered immunity.";
RL Cell Host Microbe 16:787-794(2014).
CC -!- FUNCTION: May play a role in transcriptional processes
CC (PubMed:21875893). Regulates negatively the senescence and chlorotic
CC lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars,
CC darkness) agents, probably by controlling programmed cell death (pcd)
CC (PubMed:11846876,PubMed:9338960, Ref.6, PubMed:11728314). Negative
CC regulator of plant programmed cell death (PCD) and effector-triggered
CC immunity (ETI) (PubMed:25455564). Promotes cell division and
CC endoreduplication (e.g. in trichomes) (PubMed:11728314).
CC {ECO:0000269|PubMed:11728314, ECO:0000269|PubMed:11846876,
CC ECO:0000269|PubMed:25455564, ECO:0000269|PubMed:9338960,
CC ECO:0000269|Ref.6, ECO:0000305|PubMed:21875893}.
CC -!- SUBUNIT: Interacts with SIM and SMR1 (PubMed:25455564).
CC {ECO:0000269|PubMed:25455564}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Nucleus membrane {ECO:0000269|PubMed:21875893,
CC ECO:0000269|PubMed:25455564}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11846876}.
CC -!- DISRUPTION PHENOTYPE: Plants are more resistant to pathogens such as
CC P.syringea and P.parasitica and develops spontaneous lesions.
CC {ECO:0000269|PubMed:9338960}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB79495.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB063329; BAB79495.1; ALT_INIT; mRNA.
DR EMBL; AB019236; BAA97305.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97971.1; -; Genomic_DNA.
DR EMBL; AY033229; AAK56393.1; -; mRNA.
DR RefSeq; NP_569003.1; NM_125892.4.
DR AlphaFoldDB; Q9LV85; -.
DR BioGRID; 21859; 3.
DR STRING; 3702.AT5G64930.1; -.
DR TCDB; 8.A.138.1.1; the constitutive expresser of pathogenesis-related 5 (cpr5) family.
DR iPTMnet; Q9LV85; -.
DR PaxDb; Q9LV85; -.
DR PRIDE; Q9LV85; -.
DR ProteomicsDB; 220441; -.
DR EnsemblPlants; AT5G64930.1; AT5G64930.1; AT5G64930.
DR GeneID; 836617; -.
DR Gramene; AT5G64930.1; AT5G64930.1; AT5G64930.
DR KEGG; ath:AT5G64930; -.
DR Araport; AT5G64930; -.
DR TAIR; locus:2177699; AT5G64930.
DR eggNOG; ENOG502QU8R; Eukaryota.
DR HOGENOM; CLU_029740_2_0_1; -.
DR InParanoid; Q9LV85; -.
DR OMA; YWEVLCS; -.
DR OrthoDB; 468996at2759; -.
DR PhylomeDB; Q9LV85; -.
DR PRO; PR:Q9LV85; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LV85; baseline and differential.
DR Genevisible; Q9LV85; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; TAS:TAIR.
DR GO; GO:0005635; C:nuclear envelope; IDA:TAIR.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0007568; P:aging; IMP:TAIR.
DR GO; GO:0006952; P:defense response; TAS:TAIR.
DR GO; GO:0010150; P:leaf senescence; IMP:TAIR.
DR GO; GO:0048573; P:photoperiodism, flowering; IMP:TAIR.
DR GO; GO:0009723; P:response to ethylene; IMP:TAIR.
DR GO; GO:0010182; P:sugar mediated signaling pathway; TAS:TAIR.
DR GO; GO:0009627; P:systemic acquired resistance; IMP:TAIR.
DR GO; GO:0010090; P:trichome morphogenesis; IMP:TAIR.
DR InterPro; IPR044708; CPR5.
DR PANTHER; PTHR35322; PTHR35322; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..564
FT /note="Protein CPR-5"
FT /id="PRO_0000244568"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 535
FT /note="P->S: In hys1-2; early senescence, enhanced
FT chlorosis, hypersensitivity to sugars-mediated growth
FT inhibition, and abnormal trichomes."
FT /evidence="ECO:0000269|PubMed:11846876"
SQ SEQUENCE 564 AA; 63112 MW; E3034C6311AEA07C CRC64;
MEALLLPPSP EPQNQITNPA NSKPNHQSGD VHKDETMMMK KKKDTNPSNL EKRKLKGKKK
EIMDNDEASS SYCSTSSTSN SNSTKRVTRV VHRLRNPMRL GMARRSVGER QAEKLAKPLG
FSLAAFANMV IARKNAAGQN VYVDDLVEIF ATLVEESLAN VYGNKLGSFA TNFEQTFSST
LKILKLTNEC ANPHQSNNND GGSCNLDRST IDGCSDTELF ERETSSATSA YEVMQGSATA
TSLMNELALF EETLQLSCVP PRSSAMALTT DERFLKEQTR ANDLKTVEIG LQIRELRCKE
TALGLKFESN NLGKAALELD VSKAAFRAEK FKTELEDTRK EEMVTRIMDW LLVSVFSMLA
SMVLGVYNFS IKRIEDATSV CDQSEEKSSS WWVPKQVSSI NSGFNTFICR VRVWVQIFFG
VLMIIVFTYF LNKRSSGTKQ TMPISFIVLF LGIFCGVSGK LCVDTLGGDG KLWLIVWEVF
CLLQFVANVF TLALYGLMFG PINVTQETRS NRCNSMFPYW ARRSVVYVVI LFVLPVINGL
LPFATFGEWR DFAMYHLHGG SDYA
