CPR5_CAEEL
ID CPR5_CAEEL Reviewed; 344 AA.
AC P43509;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Cathepsin B-like cysteine proteinase 5;
DE EC=3.4.22.-;
DE AltName: Full=Cysteine protease-related 5;
DE Flags: Precursor;
GN Name=cpr-5; ORFNames=W07B8.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Bristol N2;
RX PubMed=8561899; DOI=10.1089/dna.1996.15.75;
RA Larminie C.G.C., Johnstone I.L.;
RT "Isolation and characterization of four developmentally regulated cathepsin
RT B-like cysteine protease genes from the nematode Caenorhabditis elegans.";
RL DNA Cell Biol. 15:75-82(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC ECO:0000255|PROSITE-ProRule:PRU10090}.
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DR EMBL; L39896; AAA98786.1; -; mRNA.
DR EMBL; L39927; AAA98784.1; -; Genomic_DNA.
DR EMBL; FO081739; CCD74289.1; -; Genomic_DNA.
DR PIR; T37277; T37277.
DR RefSeq; NP_503383.1; NM_070982.6.
DR AlphaFoldDB; P43509; -.
DR SMR; P43509; -.
DR BioGRID; 43681; 19.
DR DIP; DIP-25329N; -.
DR IntAct; P43509; 3.
DR STRING; 6239.W07B8.5; -.
DR MEROPS; C01.A35; -.
DR EPD; P43509; -.
DR PaxDb; P43509; -.
DR PeptideAtlas; P43509; -.
DR EnsemblMetazoa; W07B8.5.1; W07B8.5.1; WBGene00000785.
DR GeneID; 178612; -.
DR KEGG; cel:CELE_W07B8.5; -.
DR UCSC; W07B8.5.1; c. elegans.
DR CTD; 178612; -.
DR WormBase; W07B8.5; CE14682; WBGene00000785; cpr-5.
DR eggNOG; KOG1543; Eukaryota.
DR GeneTree; ENSGT00970000196395; -.
DR HOGENOM; CLU_012184_3_3_1; -.
DR InParanoid; P43509; -.
DR OMA; VHNIEGI; -.
DR OrthoDB; 865289at2759; -.
DR PhylomeDB; P43509; -.
DR PRO; PR:P43509; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00000785; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hydrolase; Protease; Reference proteome; Signal;
KW Thiol protease; Zymogen.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT PROPEP 16..81
FT /evidence="ECO:0000255"
FT /id="PRO_0000026196"
FT CHAIN 82..344
FT /note="Cathepsin B-like cysteine proteinase 5"
FT /id="PRO_0000026197"
FT ACT_SITE 110
FT /evidence="ECO:0000250"
FT ACT_SITE 286
FT /evidence="ECO:0000250"
FT ACT_SITE 306
FT /evidence="ECO:0000250"
FT DISULFID 95..124
FT /evidence="ECO:0000250"
FT DISULFID 107..154
FT /evidence="ECO:0000250"
FT DISULFID 143..213
FT /evidence="ECO:0000250"
FT DISULFID 144..150
FT /evidence="ECO:0000250"
FT DISULFID 183..217
FT /evidence="ECO:0000250"
FT DISULFID 191..203
FT /evidence="ECO:0000250"
SQ SEQUENCE 344 AA; 37391 MW; E522A6559040815D CRC64;
MWKLSAILLV AAASAVVIPG HREAPALTGQ ALIDYVNSAQ KLWTAGHQVI PKEKITKKLM
DVKYLVPHKD EDIVATEVSD AIPDHFDARD QWPNCMSINN IRDQSDCGSC WAFAAAEAIS
DRTCIASNGA VNTLLSSEDL LSCCTGMFSC GNGCEGGYPI QAWKWWVKHG LVTGGSYETQ
FGCKPYSIAP CGETVNGVKW PACPEDTEPT PKCVDSCTSK NNYATPYLQD KHFGSTAYAV
GKKVEQIQTE ILTNGPIEVA FTVYEDFYQY TTGVYVHTAG ASLGGHAVKI LGWGVDNGTP
YWLVANSWNV AWGEKGYFRI IRGLNECGIE HSAVAGIPDL ARHN
