ID   CPROH_CONVC             Reviewed;         196 AA.
AC   A0A0F7YYX3;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2015, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Neuropeptide prohormone-4 {ECO:0000303|PubMed:26301480};
DE   Flags: Precursor;
OS   Conus victoriae (Queen Victoria cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=319920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=24505301; DOI=10.1371/journal.pone.0087648;
RA   Robinson S.D., Safavi-Hemami H., McIntosh L.D., Purcell A.W., Norton R.S.,
RA   Papenfuss A.T.;
RT   "Diversity of conotoxin gene superfamilies in the venomous snail, Conus
RT   victoriae.";
RL   PLoS ONE 9:E87648-E87648(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-36, MASS SPECTROMETRY,
RP   SUBUNIT, AND DISULFIDE BOND.
RX   PubMed=26301480; DOI=10.1016/j.ygcen.2015.07.012;
RA   Robinson S.D., Li Q., Bandyopadhyay P.K., Gajewiak J., Yandell M.,
RA   Papenfuss A.T., Purcell A.W., Norton R.S., Safavi-Hemami H.;
RT   "Hormone-like peptides in the venoms of marine cone snails.";
RL   Gen. Comp. Endocrinol. 244:11-18(2017).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26301480}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:26301480}.
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DR   EMBL; GAIH01000103; JAI08986.1; -; mRNA.
DR   AlphaFoldDB; A0A0F7YYX3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 4.10.400.10; -; 1.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   SMART; SM00192; LDLa; 1.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000269|PubMed:26301480"
FT   PEPTIDE         26..196
FT                   /note="Neuropeptide prohormone-4"
FT                   /id="PRO_0000439366"
FT   DOMAIN          50..90
FT                   /note="LDL-receptor class A"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        51..65
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        59..78
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        72..89
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   196 AA;  22135 MW;  3E8FA010009F2731 CRC64;
     MSSPLRMDVT FLLAAIAVTW VCGLKIGFPG FSTPPRSFIQ HPKRTLCPED CDIASPFKCE
     ESPTCLRLFQ VCNGRWDCEH GSDEDNALCA AVLRPLECMI WEFLEGQRDW ILPNLFNDAN
     TDLVAHALHE AYSMGDLQSY LNLTDQNIEN IRNSTRGAIV GDPRPLMALG MPDRAWPEVM
     YLLKELYNLG LDVWAE