ID   CPS1A_ACTSU             Reviewed;         370 AA.
AC   Q84CH1;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Capsular polysaccharide phosphotransferase;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein;
OS   Actinobacillus suis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=716;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SO4 / Serotype K1;
RA   Slavic D., MacInnes J.I.;
RT   "Capsular gene cluster of Actinobacillus suis K1.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- FUNCTION: Part of a capsular polysaccharide synthesis locus.
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY253301; AAO65491.1; -; Genomic_DNA.
DR   RefSeq; WP_039195563.1; NZ_MTBW01000072.1.
DR   AlphaFoldDB; Q84CH1; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..370
FT                   /note="Capsular polysaccharide phosphotransferase"
FT                   /id="PRO_0000235942"
SQ   SEQUENCE   370 AA;  43946 MW;  D6D3B4057F9733F6 CRC64;
     MNKMNRKFSK LLKNPHIFFR DFLNKKYPIK NTELPFAESE EANLIEAHQK LDKIIQKNTL
     RQSDIDVVFT WVDGSDPLWQ SKYHQYAPNY QANSALYATD IARFEDHNEL YYSVHAVLKF
     MPWVRHIFIV TDNQKPKWLD EAYQEKITLI SHQDIIDKEY LPTFNSHVIE AFLHKIPNLS
     ENFIYFNDDV FIARELQAEH FFQANGIASI FMSEKSLTQM RDRGTITPTL SASEYSIRLL
     NKYYNTNIDS PLVHTYIPLK KSMYELAWQR YEKEILGFLP NKLRTNHDLN FANFLIPWLM
     YFEGKAMPKI DICYYFNIRS PNALTQYKKL LNKKNIGEQP NSFCANDFNS QKSINNYQNQ
     LFSFLNSYYS