CPS1_ACTPL
ID CPS1_ACTPL Reviewed; 364 AA.
AC Q8KSB4;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Capsular polysaccharide phosphotransferase cps1A;
DE EC=2.7.-.-;
DE AltName: Full=Stealth protein cps1A;
GN Name=cps1A;
OS Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=715;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 27088 / DSM 13472 / CCM 5869 / S4074 / Serotype 1;
RX PubMed=12761114; DOI=10.1128/iai.71.6.3320-3328.2003;
RA Bandara A.B., Lawrence M.L., Veit H.P., Inzana T.J.;
RT "Association of Actinobacillus pleuropneumoniae capsular polysaccharide
RT with virulence in pigs.";
RL Infect. Immun. 71:3320-3328(2003).
RN [2]
RP IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT "Stealth proteins: in silico identification of a novel protein family
RT rendering bacterial pathogens invisible to host immune defense.";
RL PLoS Comput. Biol. 1:492-499(2005).
CC -!- FUNCTION: Part of a capsular polysaccharide synthesis locus.
CC -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC conserved from bacteria to higher eukaryotes. Family members were first
CC identified in microbes as proteins that help pathogens to elude the
CC host innate immune system. Microbial stealth proteins are involved in
CC the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC to function as hexose-1-phosphoryltransferases.
CC -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR EMBL; AF518558; AAM69355.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8KSB4; -.
DR GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR031358; Stealth_CR1.
DR InterPro; IPR021520; Stealth_CR2.
DR Pfam; PF17101; Stealth_CR1; 1.
DR Pfam; PF11380; Stealth_CR2; 1.
PE 3: Inferred from homology;
KW Exopolysaccharide synthesis; Transferase.
FT CHAIN 1..364
FT /note="Capsular polysaccharide phosphotransferase cps1A"
FT /id="PRO_0000235940"
SQ SEQUENCE 364 AA; 43244 MW; 63159D113F19E4BC CRC64;
MTKMNRKFSK LLKNPHIFFR DFLNKKYPIK NTELPFSESE EANLIEANQK LDKIIQKNTL
QQTNIDVVFT WVDGSDPSWQ AKYSQYAPNY QAKSALYATD IARFEDHNEL YYSVHAVLKY
MPWVRHIFII TDNQKPKWLD ETRQEKITLI DHQDIIDKEY LPTFNSHVIE AFLHKIPNLS
ENFIYFNDDV FIARELQAEH FFQANGIASI FMSEKSLTQM RNRGTITPTL SASEYSIRLL
NKYYNTNIDS PLVHTYIPLK KSMYELAWRR YEKEILGFLP NKFRTNNDLN FANFLIPWLM
YFEGKAMPKI DICYYFNIRS PNALTQYKKL LNKKNIGEQL IHFAQMILIV KKVLTTIKIN
CFLF