CPS4L_HUMAN
ID CPS4L_HUMAN Reviewed; 179 AA.
AC A6NMK7; A8MU95; B2RXI9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Putative cleavage and polyadenylation specificity factor subunit 4-like protein;
GN Name=CPSF4L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the CPSF4/YTH1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AC087301; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC087301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC157870; AAI57871.1; -; mRNA.
DR CCDS; CCDS45768.1; -.
DR RefSeq; NP_001123357.1; NM_001129885.1.
DR AlphaFoldDB; A6NMK7; -.
DR SMR; A6NMK7; -.
DR BioGRID; 568295; 11.
DR IntAct; A6NMK7; 7.
DR STRING; 9606.ENSP00000343900; -.
DR iPTMnet; A6NMK7; -.
DR PhosphoSitePlus; A6NMK7; -.
DR BioMuta; CPSF4L; -.
DR jPOST; A6NMK7; -.
DR MassIVE; A6NMK7; -.
DR MaxQB; A6NMK7; -.
DR PaxDb; A6NMK7; -.
DR PeptideAtlas; A6NMK7; -.
DR PRIDE; A6NMK7; -.
DR ProteomicsDB; 1543; -.
DR Antibodypedia; 51445; 84 antibodies from 14 providers.
DR DNASU; 642843; -.
DR Ensembl; ENST00000344935.8; ENSP00000343900.4; ENSG00000187959.9.
DR GeneID; 642843; -.
DR KEGG; hsa:642843; -.
DR MANE-Select; ENST00000344935.8; ENSP00000343900.4; NM_001129885.1; NP_001123357.1.
DR UCSC; uc010dfk.1; human.
DR CTD; 642843; -.
DR DisGeNET; 642843; -.
DR GeneCards; CPSF4L; -.
DR HGNC; HGNC:33632; CPSF4L.
DR HPA; ENSG00000187959; Not detected.
DR neXtProt; NX_A6NMK7; -.
DR OpenTargets; ENSG00000187959; -.
DR PharmGKB; PA162382768; -.
DR VEuPathDB; HostDB:ENSG00000187959; -.
DR eggNOG; KOG1040; Eukaryota.
DR GeneTree; ENSGT00940000162882; -.
DR HOGENOM; CLU_024513_2_0_1; -.
DR InParanoid; A6NMK7; -.
DR OMA; FRHDDGE; -.
DR OrthoDB; 1472764at2759; -.
DR PhylomeDB; A6NMK7; -.
DR TreeFam; TF314871; -.
DR PathwayCommons; A6NMK7; -.
DR SignaLink; A6NMK7; -.
DR BioGRID-ORCS; 642843; 17 hits in 1069 CRISPR screens.
DR ChiTaRS; CPSF4L; human.
DR GenomeRNAi; 642843; -.
DR Pharos; A6NMK7; Tdark.
DR PRO; PR:A6NMK7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NMK7; protein.
DR Bgee; ENSG00000187959; Expressed in right uterine tube and 82 other tissues.
DR ExpressionAtlas; A6NMK7; baseline and differential.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IBA:GO_Central.
DR InterPro; IPR045348; CPSF4/Yth1.
DR InterPro; IPR041686; Znf-CCCH_3.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR23102; PTHR23102; 1.
DR Pfam; PF15663; zf-CCCH_3; 1.
DR SMART; SM00356; ZnF_C3H1; 5.
DR SUPFAM; SSF90229; SSF90229; 2.
DR PROSITE; PS50103; ZF_C3H1; 5.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..179
FT /note="Putative cleavage and polyadenylation specificity
FT factor subunit 4-like protein"
FT /id="PRO_0000317366"
FT ZN_FING 35..61
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 62..89
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 90..117
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 118..145
FT /note="C3H1-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 146..169
FT /note="C3H1-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 179 AA; 20727 MW; A0FF66DECA37DE2C CRC64;
MQEVIAGLER FTFAFEKDVE MQKGTGLLPF QGMDKSASAV CNFFTKGLCE KGKLCPFRHD
RGEKMVVCKH WLRGLCKKGD HCKFLHQYDL TRMPECYFYS KFGDCSNKEC SFLHVKPAFK
SQDCPWYDQG FCKDGPLCKY RHVPRIMCLN YLVGFCPEGP KCQFAQKIRE FKLLPGSKI
