ID   CPSB_STRAG              Reviewed;         243 AA.
AC   P0C0T7; P0A365; Q9S0S9;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Tyrosine-protein phosphatase CpsB;
DE            EC=3.1.3.48;
GN   Name=cpsB; Synonyms=cpsIaB;
OS   Streptococcus agalactiae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NT6 / Serotype VI;
RA   McKinnon K., Chaffin D.O., Rubens C.E.;
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV;
RA   McKinnon K., Chaffin D.O., Rubens C.E.;
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Dephosphorylates CpsD. Involved in the regulation of capsular
CC       polysaccharide biosynthesis (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       CpsB/CapC family. {ECO:0000305}.
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DR   EMBL; AF337958; AAK11659.1; -; Genomic_DNA.
DR   EMBL; AF355776; AAK43603.1; -; Genomic_DNA.
DR   RefSeq; WP_000565383.1; NZ_WNJK01000002.1.
DR   AlphaFoldDB; P0C0T7; -.
DR   SMR; P0C0T7; -.
DR   OMA; VHPERNS; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR016667; Caps_polysacc_synth_CpsB/CapC.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR39181; PTHR39181; 1.
DR   Pfam; PF19567; CpsB_CapC; 1.
DR   PIRSF; PIRSF016557; Caps_synth_CpsB; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Exopolysaccharide synthesis; Hydrolase;
KW   Manganese; Protein phosphatase.
FT   CHAIN           1..243
FT                   /note="Tyrosine-protein phosphatase CpsB"
FT                   /id="PRO_0000057887"
SQ   SEQUENCE   243 AA;  28600 MW;  319CA48CCB310123 CRC64;
     MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET PEDIIFKNFS
     IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN NTKFALIEFS MQTSWKDIHT
     ALSNVLMLGI TPVVAHIERY NALENQKERV KEIINMGCYT QINSSHILKQ KLFNDKHKRF
     KKRARYFLEE NLVHFVASDM HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN
     HYI