ID   CPSC_STRA1              Reviewed;         230 AA.
AC   Q3K0S9; Q93TJ3; Q9S0S8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CpsC;
GN   Name=cpsC; Synonyms=cpsIaC; OrderedLocusNames=SAK_1260;
OS   Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC
OS   SS700).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=205921;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=OI1 / Serotype Ia;
RX   PubMed=10464185; DOI=10.1128/jb.181.17.5176-5184.1999;
RA   Yamamoto S., Miyake K., Koike Y., Watanabe M., Machida Y., Ohta M.,
RA   Iijima S.;
RT   "Molecular characterization of type-specific capsular polysaccharide
RT   biosynthesis genes of Streptococcus agalactiae type Ia.";
RL   J. Bacteriol. 181:5176-5184(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27591 / A909 / CDC SS700;
RX   PubMed=16172379; DOI=10.1073/pnas.0506758102;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D.,
RA   Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T.,
RA   Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D.,
RA   Hauser C.R., Sundaram J.P., Nelson W.C., Madupu R., Brinkac L.M.,
RA   Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H.,
RA   Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D.,
RA   Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O.,
RA   Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L.,
RA   Wessels M.R., Rappuoli R., Fraser C.M.;
RT   "Genome analysis of multiple pathogenic isolates of Streptococcus
RT   agalactiae: implications for the microbial 'pan-genome'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005).
RN   [3]
RP   FUNCTION.
RC   STRAIN=515 / Serotype Ia;
RX   PubMed=11027683; DOI=10.1074/jbc.m005702200;
RA   Cieslewicz M.J., Kasper D.L., Wang Y., Wessels M.R.;
RT   "Functional analysis in type Ia group B Streptococcus of a cluster of genes
RT   involved in extracellular polysaccharide production by diverse species of
RT   Streptococci.";
RL   J. Biol. Chem. 276:139-146(2001).
CC   -!- FUNCTION: Required for CpsD phosphorylation (By similarity). Involved
CC       in the regulation of capsular polysaccharide biosynthesis. May be part
CC       of a complex that directs the coordinated polymerization and export to
CC       the cell surface of the capsular polysaccharide. {ECO:0000250,
CC       ECO:0000269|PubMed:11027683}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB028896; BAA82277.1; -; Genomic_DNA.
DR   EMBL; CP000114; ABA45263.1; -; Genomic_DNA.
DR   RefSeq; WP_001033072.1; NC_007432.1.
DR   AlphaFoldDB; Q3K0S9; -.
DR   SMR; Q3K0S9; -.
DR   KEGG; sak:SAK_1260; -.
DR   HOGENOM; CLU_082668_0_1_9; -.
DR   OMA; NRNQGDK; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..230
FT                   /note="Capsular polysaccharide biosynthesis protein CpsC"
FT                   /id="PRO_0000217229"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        51
FT                   /note="T -> I (in Ref. 1; BAA82277)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   230 AA;  25185 MW;  F0EF0EF6D8CFC9AF CRC64;
     MNKIANTEVE INIFNLLKKL WKKKFLITFV AIAFATAGLF YSLFIVTPQY TSSTRIYVIN
     PNTPNNSITA QDLQAGSFLA NDYKEIITST DVLEKVISSE KLNYPSSQLL QKITVSILKD
     TRVISISVED ANPKMSQKLA NSVREAAVSK IKAVTQVEDI TTLEKGNLPK APSSPNIKKN
     VLIGFIVGAG LSTIVLVIMG ILDDRVNTEE DIEKALGLTS LGIVPDLNKL