CPSC_STRA3
ID CPSC_STRA3 Reviewed; 230 AA.
AC Q04662;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 17-JAN-2003, sequence version 2.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Capsular polysaccharide biosynthesis protein CpsC;
GN Name=cpsC; OrderedLocusNames=gbs1246;
OS Streptococcus agalactiae serotype III (strain NEM316).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=211110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=COH1 / Serotype III;
RX PubMed=8355611; DOI=10.1111/j.1365-2958.1993.tb01631.x;
RA Rubens C.E., Heggen L.M., Haft R.F., Wessels M.R.;
RT "Identification of cpsD, a gene essential for type III capsule expression
RT in group B streptococci.";
RL Mol. Microbiol. 8:843-855(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316;
RX PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
CC -!- FUNCTION: Required for CpsD phosphorylation. Involved in the regulation
CC of capsular polysaccharide biosynthesis. May be part of a complex that
CC directs the coordinated polymerization and export to the cell surface
CC of the capsular polysaccharide (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
CC -!- CAUTION: Was originally called CpsB. {ECO:0000305|PubMed:8355611}.
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DR EMBL; AF163833; AAB00362.1; -; Genomic_DNA.
DR EMBL; AL766849; CAD46905.1; -; Genomic_DNA.
DR RefSeq; WP_001033074.1; NC_004368.1.
DR AlphaFoldDB; Q04662; -.
DR SMR; Q04662; -.
DR STRING; 211110.gbs1245; -.
DR EnsemblBacteria; CAD46905; CAD46905; CAD46905.
DR KEGG; san:cpsC; -.
DR eggNOG; COG3944; Bacteria.
DR HOGENOM; CLU_082668_0_1_9; -.
DR OMA; NRNQGDK; -.
DR UniPathway; UPA00934; -.
DR Proteomes; UP000000823; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR Pfam; PF02706; Wzz; 1.
PE 3: Inferred from homology;
KW Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..230
FT /note="Capsular polysaccharide biosynthesis protein CpsC"
FT /id="PRO_0000217226"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 225
FT /note="S -> P (in Ref. 1; AAB00362)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 230 AA; 25203 MW; 27BF0EF6D8CD19BD CRC64;
MNKIANTEVE INIFNLLKKL WKKKFLITFV AIAFATAGLF YSLFIVTPQY TSSTRIYVIN
PNTPNNSITA QDLQAGSFLA NDYKEIITST DVLEKVISSE KLNYPSSQLL QKITVSILKD
TRVISISVED ANPKMSQKLA NSVREAAVSK IKAVTQVEDI TTLEKGNLPK APSSPNIKKN
VLIGFIVGAG LSTIVLVIMG ILDDRVNTEE DIEKVLGLTS LGIVSDLNKL
