ID   CPSC_STRA5              Reviewed;         230 AA.
AC   P59221;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   17-JAN-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CpsC;
GN   Name=cpsC; OrderedLocusNames=SAG1173;
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CNCTC 1/82 / Serotype V;
RA   McKinnon K., Chaffin D.O., Rubens C.E.;
RT   "Streptococcus agalactiae type V polysaccharide synthesis operon complete
RT   sequence.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R;
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA   Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA   Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA   Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA   Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- FUNCTION: Required for CpsD phosphorylation. Involved in the regulation
CC       of capsular polysaccharide biosynthesis. May be part of a complex that
CC       directs the coordinated polymerization and export to the cell surface
CC       of the capsular polysaccharide (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; AF349539; AAK29649.1; -; Genomic_DNA.
DR   EMBL; AE009948; AAN00055.1; -; Genomic_DNA.
DR   PIR; S34975; S34975.
DR   RefSeq; NP_688182.1; NC_004116.1.
DR   RefSeq; WP_001033073.1; NC_004116.1.
DR   AlphaFoldDB; P59221; -.
DR   SMR; P59221; -.
DR   STRING; 208435.SAG1173; -.
DR   EnsemblBacteria; AAN00055; AAN00055; SAG1173.
DR   GeneID; 66886097; -.
DR   KEGG; sag:SAG1173; -.
DR   PATRIC; fig|208435.3.peg.1179; -.
DR   HOGENOM; CLU_082668_0_1_9; -.
DR   OMA; NRNQGDK; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..230
FT                   /note="Capsular polysaccharide biosynthesis protein CpsC"
FT                   /id="PRO_0000217227"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   230 AA;  25213 MW;  27BF0EF6D8CFC9BD CRC64;
     MNKIANTEVE INIFNLLKKL WKKKFLITFV AIAFATAGLF YSLFIVTPQY TSSTRIYVIN
     PNTPNNSITA QDLQAGSFLA NDYKEIITST DVLEKVISSE KLNYPSSQLL QKITVSILKD
     TRVISISVED ANPKMSQKLA NSVREAAVSK IKAVTQVEDI TTLEKGNLPK APSSPNIKKN
     VLIGFIVGAG LSTIVLVIMG ILDDRVNTEE DIEKVLGLTS LGIVPDLNKL