ID   CPSC_STRAG              Reviewed;         230 AA.
AC   P0C0T8; Q93TJ3; Q9S0S8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CpsC;
GN   Name=cpsC; Synonyms=cpsIaC;
OS   Streptococcus agalactiae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NT6 / Serotype VI;
RA   McKinnon K., Chaffin D.O., Rubens C.E.;
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV;
RA   McKinnon K., Chaffin D.O., Rubens C.E.;
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for CpsD phosphorylation (By similarity). Involved
CC       in the regulation of capsular polysaccharide biosynthesis. May be part
CC       of a complex that directs the coordinated polymerization and export to
CC       the cell surface of the capsular polysaccharide (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; AF337958; AAK11660.1; -; Genomic_DNA.
DR   EMBL; AF355776; AAK43604.1; -; Genomic_DNA.
DR   RefSeq; WP_001033068.1; NZ_VSKR01000007.1.
DR   RefSeq; WP_001033073.1; NZ_WNJK01000002.1.
DR   AlphaFoldDB; P0C0T8; -.
DR   SMR; P0C0T8; -.
DR   GeneID; 66886097; -.
DR   OrthoDB; 1184929at2; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..230
FT                   /note="Capsular polysaccharide biosynthesis protein CpsC"
FT                   /id="PRO_0000217228"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         115
FT                   /note="V -> I (in strain: CNTC 1/82)"
SQ   SEQUENCE   230 AA;  25213 MW;  27BF0EF6D8CFC9BD CRC64;
     MNKIANTEVE INIFNLLKKL WKKKFLITFV AIAFATAGLF YSLFIVTPQY TSSTRIYVIN
     PNTPNNSITA QDLQAGSFLA NDYKEIITST DVLEKVISSE KLNYPSSQLL QKITVSILKD
     TRVISISVED ANPKMSQKLA NSVREAAVSK IKAVTQVEDI TTLEKGNLPK APSSPNIKKN
     VLIGFIVGAG LSTIVLVIMG ILDDRVNTEE DIEKVLGLTS LGIVPDLNKL