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CPSC_STRPN
ID   CPSC_STRPN              Reviewed;         230 AA.
AC   Q97SJ6;
DT   01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Capsular polysaccharide biosynthesis protein CpsC;
GN   Name=cpsC; OrderedLocusNames=SP_0348;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Required for CpsD phosphorylation. Involved in the regulation
CC       of capsular polysaccharide biosynthesis. May be part of a complex that
CC       directs the coordinated polymerization and export to the cell surface
CC       of the capsular polysaccharide (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK74521.1; -; Genomic_DNA.
DR   PIR; H95040; H95040.
DR   RefSeq; WP_000664160.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97SJ6; -.
DR   STRING; 170187.SP_0348; -.
DR   EnsemblBacteria; AAK74521; AAK74521; SP_0348.
DR   KEGG; spn:SP_0348; -.
DR   eggNOG; COG3944; Bacteria.
DR   OMA; NRNQGDK; -.
DR   PhylomeDB; Q97SJ6; -.
DR   BioCyc; SPNE170187:G1FZB-358-MON; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   InterPro; IPR005701; MPA1-like.
DR   Pfam; PF02706; Wzz; 1.
DR   TIGRFAMs; TIGR01006; polys_exp_MPA1; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..230
FT                   /note="Capsular polysaccharide biosynthesis protein CpsC"
FT                   /id="PRO_0000217230"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   230 AA;  25449 MW;  66756831BA9B9E1D CRC64;
     MKEQNTIEID VFQLVKSLWK RKLMILIVAL VTGAGAFAYS TFIVKPEYTS TTRIYVVNRN
     QGDKPGLTNQ DLQAGTYLVK DYREIILSQD VLEEVVSDLK LDLTPKGLAN KIKVTVPVDT
     RIVSISVNDR VPEEASRIAN SLREVAAQKI ISITRVSDVT TLEEARPAIS PSSPNIKRNT
     LIGFLAGVIG TSVIVLHLEL LDTRVKRPED IENTLQMTLL GVVPNLGKLK
 
 
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