CPSFX_SCHPO
ID CPSFX_SCHPO Reviewed; 710 AA.
AC O74535; O14392;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Cleavage and polyadenylation factor complex subunit C74.02c;
GN ORFNames=SPCC74.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 142-216.
RC STRAIN=972 / ATCC 24843;
RA Jang Y.-J., Yoo H.-S.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION IN THE CPF COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=14617822; DOI=10.1074/mcp.m300081-mcp200;
RA Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F.,
RA Shevchenko A.;
RT "A comparative analysis of an orthologous proteomic environment in the
RT yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.";
RL Mol. Cell. Proteomics 3:125-132(2004).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC factor (CPF) complex, which plays a key role in polyadenylation-
CC dependent pre-mRNA 3'-end formation. Involved in poly(A) site
CC recognition. May be involved in coupling transcription termination and
CC mRNA 3'-end formation.
CC -!- SUBUNIT: Component of the cleavage and polyadenylation factor (CPF)
CC complex. {ECO:0000269|PubMed:14617822}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA20832.1; -; Genomic_DNA.
DR EMBL; U97391; AAB63883.1; -; mRNA.
DR PIR; T41586; T41586.
DR RefSeq; NP_588375.1; NM_001023366.2.
DR AlphaFoldDB; O74535; -.
DR SMR; O74535; -.
DR BioGRID; 275979; 24.
DR IntAct; O74535; 2.
DR MINT; O74535; -.
DR STRING; 4896.SPCC74.02c.1; -.
DR iPTMnet; O74535; -.
DR MaxQB; O74535; -.
DR PaxDb; O74535; -.
DR EnsemblFungi; SPCC74.02c.1; SPCC74.02c.1:pep; SPCC74.02c.
DR GeneID; 2539414; -.
DR KEGG; spo:SPCC74.02c; -.
DR PomBase; SPCC74.02c; -.
DR VEuPathDB; FungiDB:SPCC74.02c; -.
DR eggNOG; ENOG502S92D; Eukaryota.
DR HOGENOM; CLU_388904_0_0_1; -.
DR InParanoid; O74535; -.
DR OMA; KTPHIYG; -.
DR PRO; PR:O74535; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:1990567; C:DPS complex; IDA:PomBase.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006379; P:mRNA cleavage; IC:PomBase.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cytoplasm; mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..710
FT /note="Cleavage and polyadenylation factor complex subunit
FT C74.02c"
FT /id="PRO_0000351430"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 77225 MW; F36A405055D4736F CRC64;
MDNWNSVRNV SSDRQTSKTS ENPPHTSNEY SGKPEFINLS PDLEENLDEK LMSAFPGLEP
HVFQHSQSPL SHKDASLLAT MPSVASSNPS LISSGSSQTG SPSQSLSSNK EPSSPGISPS
NDSQSQNTNH TSISANPYVN NPSHTSRNPD SGSSLNTASH EVPSSKSDVN VQMLARLKSK
SRQKISSSDP LEDLRLTLTE CLNPINIVQA PKECAAILVN LMSNITQDDQ KLVFLDLLKS
KVGNSIYSQL VDGGRKLFLP KLRNWFVSAI RSKHDELIHL ILLVLANLPL TTEKLAEVKF
GKPILIVKKK STNSVIRQLA ENLSELAEKS FTIEQNRENE KSSTKNDSTV SSSAVVMAPA
GPAMAPSASN KPSASSTTKS SNSKSKKKVT SISGTSFFKN LASSTKPTSA SSSTKAPLTK
QQTNPSTPLS SIMAGLKGRE KEKDKDSGIS SENVSNNREE LPSFRKRSSS SRQSEEIASL
QAENAVFSSD PASNDEKTGN KKRKKKSVSW KPDNDLVQVK FIESLNEEGA ASVKTPHIYG
NARDMDRQEA RVAFGSHVED DVENEIIWYK PVPIKFEISK DEIHPRGYKC GGNERNLTPE
ATSEIEREKN ESKDISTFNI ILDLPVIREF DDSRPPAHIK LVSSDTQATT ELGFNGLVQQ
VSENNTNAYS ATSNSQLSSI FSNLSSSISD ASSNVLQNPS LSIPNYSNAI
