ID   CPSY_MYCBO              Reviewed;         532 AA.
AC   Q7U184; A0A1R3XWH0; X2BG73;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Exopolysaccharide phosphotransferase CpsY;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein CpsY;
GN   Name=cpsY; OrderedLocusNames=BQ2027_MB0829C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
RN   [3]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; LT708304; SIT99428.1; -; Genomic_DNA.
DR   RefSeq; NP_854487.1; NC_002945.3.
DR   RefSeq; WP_003898594.1; NC_002945.4.
DR   AlphaFoldDB; Q7U184; -.
DR   SMR; Q7U184; -.
DR   EnsemblBacteria; SIT99428; SIT99428; BQ2027_MB0829C.
DR   PATRIC; fig|233413.5.peg.901; -.
DR   OMA; PTHNSQA; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..532
FT                   /note="Exopolysaccharide phosphotransferase CpsY"
FT                   /id="PRO_0000235947"
SQ   SEQUENCE   532 AA;  60268 MW;  248451CB250C27F5 CRC64;
     MPKISSRDGG RPAQRTVNPI IVTRRGKIAR LESGLTPQEA QIEDLVFLRK VLNRADIPYL
     LIRNHKNRPV LAINIELRAG LERALAAACA TEPMYAKTID EPGLSPVLVA TDGLSQLVDP
     RVVRLYRRRI APGGFRYGPA FGVELQFWVY EETVIRCPVE NSLSRKVLPR NEITPTNVKL
     YGYKWPTLDG MFAPHASDVV FDIDMVFSWV DGSDPEFRAR RMAQMSQYVV GEGDDAEARI
     RQIDELKYAL RSVNMFAPWI RRIFIATDST PPPWLAEHPK ITIVRAEDHF SDRSALPTYN
     SHAVESQLHH IPGLSEHFLY SNDDMFFGRP LKASMFFSPG GVTRFIEAKT RIGLGANNPA
     RSGFENAARV NRQLLFDRFG QVITRHLEHT AVPLRKSVLI EMEREFPEEF ARTAASPFRS
     DTDISVTNSF YHYYALMTGR AVPQEKAKVL YVDTTSYAGL RLLPKLRKHR GYDFFCLNDG
     SFPEVPAAQR AERVVSFLER YFPIPAPWEK IAADVSRRDF AVPRTSAPSE GA