ID   CPSY_MYCLE              Reviewed;         542 AA.
AC   Q50025; O08112;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Exopolysaccharide phosphotransferase CpsY;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein CpsY;
GN   Name=cpsY; OrderedLocusNames=ML2209; ORFNames=MLCB5.32c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; U15182; AAA62996.1; -; Genomic_DNA.
DR   EMBL; Z95151; CAB08405.1; -; Genomic_DNA.
DR   EMBL; AL583924; CAC31164.1; -; Genomic_DNA.
DR   PIR; D87185; D87185.
DR   RefSeq; NP_302449.1; NC_002677.1.
DR   RefSeq; WP_010908769.1; NC_002677.1.
DR   AlphaFoldDB; Q50025; -.
DR   STRING; 272631.ML2209; -.
DR   EnsemblBacteria; CAC31164; CAC31164; CAC31164.
DR   KEGG; mle:ML2209; -.
DR   PATRIC; fig|272631.5.peg.4184; -.
DR   Leproma; ML2209; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_033996_0_0_11; -.
DR   OMA; PTHNSQA; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Reference proteome; Transferase.
FT   CHAIN           1..542
FT                   /note="Exopolysaccharide phosphotransferase CpsY"
FT                   /id="PRO_0000235948"
FT   REGION          522..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   542 AA;  61976 MW;  C40CFE20223D54B2 CRC64;
     MSKIVSCEDD RPVRRTLEPI IVTRQGKVAR LESSLTPHEA QIEDLIFLRK ALNRADIPFL
     FIRNHKNRPV LAINIKLRPA VERALVTACA SEPMYAKTID ERGLSPVLVA KGQLSQSIDP
     RIVRLYRRRI APGGFRFGSR FGVELQFWSF EETLIRCPVE NSLTRKVLPR KEVTPATIKL
     YGYKWHTIEG MFTPHASDVT FDIDLVFSWV DGSDPEFRAR RAAEMSHHVV GEGDDADARI
     RQIDELKYAL RSVNMFAPWI RRIFIATDSI PPSWLADHPM ITIVPAEDHF SDRSALPTYN
     SHAVESQLHR IPDLSEHFLY SNDDMFFGRP LKASMFFSPG GVTRFIEAKT RIGLGTNDPT
     RSGFENAARV NRQLLLRRFG QLITRHLEHT TVPLRKSVLF EMEQEFPEEF ARTQESVFRS
     GTDISVTNSL YHYYALITGR AVQQEKAKVL YVDTTSYTGL NLLPELRKRR NYDFFCLNDG
     SFPEVPATER AERVVSFLER YFPIPAPWEK VATDFNRQDF ASPTVSAPLE DGQTANPAQT
     AR