ID   CPSY_MYCTU              Reviewed;         532 AA.
AC   P9WGD1; L0T6I2; O06628; Q7D992;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Exopolysaccharide phosphotransferase CpsY;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein CpsY;
GN   Name=cpsY; OrderedLocusNames=Rv0806c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases (PubMed:16299590).
CC       {ECO:0000305|PubMed:16299590}.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP43554.1; -; Genomic_DNA.
DR   PIR; G70536; G70536.
DR   RefSeq; NP_215321.1; NC_000962.3.
DR   RefSeq; WP_003898594.1; NZ_NVQJ01000064.1.
DR   AlphaFoldDB; P9WGD1; -.
DR   SMR; P9WGD1; -.
DR   STRING; 83332.Rv0806c; -.
DR   PaxDb; P9WGD1; -.
DR   DNASU; 885243; -.
DR   GeneID; 885243; -.
DR   KEGG; mtu:Rv0806c; -.
DR   TubercuList; Rv0806c; -.
DR   eggNOG; COG0438; Bacteria.
DR   OMA; PTHNSQA; -.
DR   PhylomeDB; P9WGD1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   1: Evidence at protein level;
KW   Exopolysaccharide synthesis; Reference proteome; Transferase.
FT   CHAIN           1..532
FT                   /note="Exopolysaccharide phosphotransferase CpsY"
FT                   /id="PRO_0000235949"
SQ   SEQUENCE   532 AA;  60268 MW;  248451CB250C27F5 CRC64;
     MPKISSRDGG RPAQRTVNPI IVTRRGKIAR LESGLTPQEA QIEDLVFLRK VLNRADIPYL
     LIRNHKNRPV LAINIELRAG LERALAAACA TEPMYAKTID EPGLSPVLVA TDGLSQLVDP
     RVVRLYRRRI APGGFRYGPA FGVELQFWVY EETVIRCPVE NSLSRKVLPR NEITPTNVKL
     YGYKWPTLDG MFAPHASDVV FDIDMVFSWV DGSDPEFRAR RMAQMSQYVV GEGDDAEARI
     RQIDELKYAL RSVNMFAPWI RRIFIATDST PPPWLAEHPK ITIVRAEDHF SDRSALPTYN
     SHAVESQLHH IPGLSEHFLY SNDDMFFGRP LKASMFFSPG GVTRFIEAKT RIGLGANNPA
     RSGFENAARV NRQLLFDRFG QVITRHLEHT AVPLRKSVLI EMEREFPEEF ARTAASPFRS
     DTDISVTNSF YHYYALMTGR AVPQEKAKVL YVDTTSYAGL RLLPKLRKHR GYDFFCLNDG
     SFPEVPAAQR AERVVSFLER YFPIPAPWEK IAADVSRRDF AVPRTSAPSE GA