ID   CPS_ACET2               Reviewed;         557 AA.
AC   Q02929; A3DBF1;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Putative sensory transducer protein;
GN   OrderedLocusNames=Cthe_0039;
OS   Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC
OS   103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Acetivibrio.
OX   NCBI_TaxID=203119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8436949; DOI=10.1099/00221287-139-2-307;
RA   Hazlewood G.P., Davidson K., Laurie J.I., Huskisson N.S., Gilbert H.J.;
RT   "Gene sequence and properties of CelI, a family E endoglucanase from
RT   Clostridium thermocellum.";
RL   J. Gen. Microbiol. 139:307-316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL
RC   B-4536 / VPI 7372;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D.,
RA   Newcomb M., Richardson P.;
RT   "Complete sequence of Clostridium thermocellum ATCC 27405.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind attractants or detect changes in the extracellular
CC       concentration of soluble sugars.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABN51280.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L04736; AAA20891.1; -; Genomic_DNA.
DR   EMBL; CP000568; ABN51280.1; ALT_INIT; Genomic_DNA.
DR   PIR; B47704; B47704.
DR   AlphaFoldDB; Q02929; -.
DR   SMR; Q02929; -.
DR   STRING; 203119.Cthe_0039; -.
DR   EnsemblBacteria; ABN51280; ABN51280; Cthe_0039.
DR   KEGG; cth:Cthe_0039; -.
DR   eggNOG; COG0840; Bacteria.
DR   HOGENOM; CLU_000445_107_16_9; -.
DR   OMA; PANQQWQ; -.
DR   Proteomes; UP000002145; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR024478; HlyB_4HB_MCP.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF12729; 4HB_MCP_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..557
FT                   /note="Putative sensory transducer protein"
FT                   /id="PRO_0000110547"
FT   TRANSMEM        122..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          147..199
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          243..472
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   REGION          511..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        511..541
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         268
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         274
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         281
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         463
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   557 AA;  61043 MW;  169875A91F614446 CRC64;
     MRYNTAKLLV YDAEQVSKGI EKIQEHVENT EKYLSLYEST VINETDRIQL QELKALWEKY
     KSLVDKEVEL VKSGKTEEAR QLLLSDIDDI GDTLRDYFEA FVEYNTTAAK EKVDENKQVA
     STASTVMIVV IFVGILIAIA LGVFISRIIS KPIGQMVEAA DRLALGDVEV DVKAETRDEI
     GKLAESFKRM IENIREQAYV VERIAAGDMT VDVRVKSDKD LLGKKLKEMV DTNNEVLSNI
     NEVAAQVAAG AKQVSDSSMQ LSQGATEQAS SIEELTASLE QVANQTQLSA KNANQANELA
     EVAKNNAEQG NKQMAEMLNA MEEINNSSSN ISRIIKVIDE IAFQTNILAL NAAVEAARAG
     QHGKGFAVVA EEVRNLAARS ANAAKETTEL IEGTIKRTEN GTKIARETAE ALNKIVEGIS
     KAATLVNDIA VASNEQAAAI TQINQGIAQV SQVVQTNSAT SEESAAASEE LSSQAELLKR
     SIAKFKLKNM GKMTSNRYKE VSPEIMRMLE DYTENKQPKS YSKEENGEYS DGKETAEKDV
     GGLKQKILLS DSEFGKY