CPVL_DICDI
ID CPVL_DICDI Reviewed; 500 AA.
AC Q869Q8; Q555H4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Probable serine carboxypeptidase CPVL;
DE EC=3.4.16.-;
DE Flags: Precursor;
GN Name=cpvl; ORFNames=DDB_G0274511;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be involved in the digestion of phagocytosed particles in
CC the lysosome, participation in an inflammatory protease cascade, and
CC trimming of peptides for antigen presentation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70148.1; -; Genomic_DNA.
DR RefSeq; XP_644095.1; XM_639003.1.
DR AlphaFoldDB; Q869Q8; -.
DR SMR; Q869Q8; -.
DR STRING; 44689.DDB0266715; -.
DR ESTHER; dicdi-Q869Q8; Carboxypeptidase_S10.
DR MEROPS; S10.003; -.
DR PaxDb; Q869Q8; -.
DR EnsemblProtists; EAL70148; EAL70148; DDB_G0274511.
DR GeneID; 8619524; -.
DR KEGG; ddi:DDB_G0274511; -.
DR dictyBase; DDB_G0274511; -.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_10_1_1; -.
DR InParanoid; Q869Q8; -.
DR OMA; PFHDLDK; -.
DR PhylomeDB; Q869Q8; -.
DR PRO; PR:Q869Q8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR033124; Ser_caboxypep_his_AS.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW Secreted; Signal; Zymogen.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000331563"
FT CHAIN ?..500
FT /note="Probable serine carboxypeptidase CPVL"
FT /id="PRO_0000331564"
FT ACT_SITE 233
FT /evidence="ECO:0000250"
FT ACT_SITE 414
FT /evidence="ECO:0000250"
FT ACT_SITE 474
FT /evidence="ECO:0000250"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 333
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 360
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 500 AA; 57061 MW; 93544531DA0F1C53 CRC64;
MKVSLSFLLT ILIVIITIKV NLSQEIKISP FFANNLKFEP IPDYIEYDSD SDAGEALFLS
NYLDDHKTAK QKSCVDIGAP FQSCDKLLEI DSNLRDTEDF FTFTGFITVN ETYNSNTFFW
FLESQNGDKN SPLVIFLQGG PGGASTFSLF VETGPYELLD NFTLVQREIT WNSEFAMLYI
DNPVGTGFSF TDSQEGYSNN EDEIATNLYT FLQQFYKLYP EYYTNELYIT GESYAGKYIP
AFSYHIIQQN QNSNNPNINL KGIAIGDGLC DPITQVTQYA NLAFYTGLAD LQQQEVMFEY
QDKIVEAINQ EQWSVANDLF TDLINGPPDY FQNITGESDY YDIRKTVEPT YGGDFTAFLN
QSSIRAMIHV GNNYFQNNND VYIHLEQDIP KSVKQLFPTI LDNIKVILYN GQFDFIVGPS
LTETMIRTIE WEGIQPFLES PKIIWKIPSD NVDVAGFVRQ WNSFTQVVVR QAGHMVPLDQ
PARAFDMIDR FINNEPFPSG
