CPVL_MOUSE
ID CPVL_MOUSE Reviewed; 478 AA.
AC Q9D3S9; B2RQB1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Probable serine carboxypeptidase CPVL;
DE EC=3.4.16.-;
DE Flags: Precursor;
GN Name=Cpvl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in the digestion of phagocytosed particles in
CC the lysosome, participation in an inflammatory protease cascade, and
CC trimming of peptides for antigen presentation. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D3S9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D3S9-2; Sequence=VSP_033260;
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
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DR EMBL; AK017087; BAB30589.1; -; mRNA.
DR EMBL; AC073297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137839; AAI37840.1; -; mRNA.
DR CCDS; CCDS51777.1; -. [Q9D3S9-1]
DR CCDS; CCDS85050.1; -. [Q9D3S9-2]
DR RefSeq; NP_001276642.1; NM_001289713.1. [Q9D3S9-1]
DR RefSeq; NP_001276643.1; NM_001289714.1. [Q9D3S9-2]
DR RefSeq; NP_082025.1; NM_027749.2. [Q9D3S9-1]
DR RefSeq; XP_006506678.1; XM_006506615.3. [Q9D3S9-1]
DR AlphaFoldDB; Q9D3S9; -.
DR SMR; Q9D3S9; -.
DR STRING; 10090.ENSMUSP00000131462; -.
DR ESTHER; mouse-CPMac; Carboxypeptidase_S10.
DR MEROPS; S10.003; -.
DR GlyGen; Q9D3S9; 4 sites.
DR iPTMnet; Q9D3S9; -.
DR PhosphoSitePlus; Q9D3S9; -.
DR PaxDb; Q9D3S9; -.
DR PRIDE; Q9D3S9; -.
DR ProteomicsDB; 285261; -. [Q9D3S9-1]
DR ProteomicsDB; 285262; -. [Q9D3S9-2]
DR Antibodypedia; 26062; 200 antibodies from 28 providers.
DR DNASU; 71287; -.
DR Ensembl; ENSMUST00000166545; ENSMUSP00000131462; ENSMUSG00000052955. [Q9D3S9-1]
DR Ensembl; ENSMUST00000203101; ENSMUSP00000145288; ENSMUSG00000052955. [Q9D3S9-2]
DR Ensembl; ENSMUST00000204674; ENSMUSP00000144942; ENSMUSG00000052955. [Q9D3S9-1]
DR GeneID; 71287; -.
DR KEGG; mmu:71287; -.
DR UCSC; uc009bzm.3; mouse. [Q9D3S9-2]
DR UCSC; uc012emc.2; mouse. [Q9D3S9-1]
DR CTD; 54504; -.
DR MGI; MGI:1918537; Cpvl.
DR VEuPathDB; HostDB:ENSMUSG00000052955; -.
DR eggNOG; KOG1282; Eukaryota.
DR GeneTree; ENSGT00940000159498; -.
DR HOGENOM; CLU_008523_10_1_1; -.
DR InParanoid; Q9D3S9; -.
DR OMA; PFHDLDK; -.
DR OrthoDB; 625787at2759; -.
DR PhylomeDB; Q9D3S9; -.
DR TreeFam; TF354323; -.
DR BioGRID-ORCS; 71287; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D3S9; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D3S9; protein.
DR Bgee; ENSMUSG00000052955; Expressed in spermatid and 14 other tissues.
DR Genevisible; Q9D3S9; MM.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Carboxypeptidase; Glycoprotein; Hydrolase; Protease;
KW Reference proteome; Signal; Zymogen.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000331586"
FT CHAIN ?..478
FT /note="Probable serine carboxypeptidase CPVL"
FT /id="PRO_0000331587"
FT ACT_SITE 206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT ACT_SITE 390
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT ACT_SITE 450
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 309
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 247..290
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033260"
SQ SEQUENCE 478 AA; 54763 MW; 3BD766AD8498A441 CRC64;
MVRAKWKMVV SLILFMVSPG DGLFHAVYRS ILVSQSFKGD AGQPLFLSPY IKNGKIKEGQ
RKSMVSPFPG MNDKSYAGYI TVNQTYNSNL FFWFFPARMQ PEDAPVVLWL QGGPGGSSMF
GLFVEHGPYI ITSNMTVVAR DFPWTFTLSM LYIDNPVGTG FSFTDHFQGY ATSEDDVAQD
LYSALIQFFT LFPEYAKNDF YVTGESYAGK YVPALAHYIH SLNPVRKFKI RLKGIAIGDA
YTDPESIIGG YAAFLYEIGL LDEQQQKYFQ KQCSKCVKYI KEQEWMKAFE ILDKLLDGDV
TTGSSFFQNV TGCTNYYNIL QCTEPKEQSY FAKFLTLPQV RQAIHVGNQN FSDGAEVEKH
LREDTVKSVK PWLSEIMNYY KVLIYNGQLD IIVAAALTER SLMAMDWKGS RAYRRARRKV
WKIFKSDNEV AGYVRRVGKF HQVIVRGGGH ILPYDQPMRS FDMINRFIYD RGWEPYNS
