ID   CPVL_RAT                Reviewed;         478 AA.
AC   Q4QR71;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Probable serine carboxypeptidase CPVL;
DE            EC=3.4.16.-;
DE   Flags: Precursor;
GN   Name=CPVL;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in the digestion of phagocytosed particles in
CC       the lysosome, participation in an inflammatory protease cascade, and
CC       trimming of peptides for antigen presentation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
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DR   EMBL; BC097471; AAH97471.1; -; mRNA.
DR   RefSeq; NP_001025098.1; NM_001029927.1.
DR   RefSeq; XP_008761137.1; XM_008762915.2.
DR   AlphaFoldDB; Q4QR71; -.
DR   SMR; Q4QR71; -.
DR   STRING; 10116.ENSRNOP00000012196; -.
DR   ESTHER; ratno-CPVL; Carboxypeptidase_S10.
DR   MEROPS; S10.003; -.
DR   GlyGen; Q4QR71; 4 sites.
DR   PhosphoSitePlus; Q4QR71; -.
DR   PaxDb; Q4QR71; -.
DR   Ensembl; ENSRNOT00000012196; ENSRNOP00000012196; ENSRNOG00000009172.
DR   GeneID; 502774; -.
DR   KEGG; rno:502774; -.
DR   UCSC; RGD:1563609; rat.
DR   CTD; 54504; -.
DR   RGD; 1563609; Cpvl.
DR   eggNOG; KOG1282; Eukaryota.
DR   GeneTree; ENSGT00940000159498; -.
DR   InParanoid; Q4QR71; -.
DR   OMA; PFHDLDK; -.
DR   OrthoDB; 625787at2759; -.
DR   PhylomeDB; Q4QR71; -.
DR   TreeFam; TF354323; -.
DR   PRO; PR:Q4QR71; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000009172; Expressed in testis and 6 other tissues.
DR   GO; GO:0004185; F:serine-type carboxypeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001563; Peptidase_S10.
DR   InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR   PANTHER; PTHR11802; PTHR11802; 1.
DR   Pfam; PF00450; Peptidase_S10; 1.
DR   PRINTS; PR00724; CRBOXYPTASEC.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE   2: Evidence at transcript level;
KW   Carboxypeptidase; Glycoprotein; Hydrolase; Protease; Reference proteome;
KW   Signal; Zymogen.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..?
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000331565"
FT   CHAIN           ?..478
FT                   /note="Probable serine carboxypeptidase CPVL"
FT                   /id="PRO_0000331566"
FT   ACT_SITE        206
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT   ACT_SITE        390
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT   ACT_SITE        450
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10074"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        309
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        350
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   478 AA;  55146 MW;  BA1ED40D3776355C CRC64;
     MVRAQWKVII LLILLMVIPS DGLFHSIYRS ILVAQPFKGN AGQPLFLSPY IRTGKIKEGQ
     RKSMVSPFPG MYDKSYAGYI TVNQTYNSNL FFWFFPARTQ PADAPVVLWL QGGPGGSSMF
     GLFVEHGPYI ITSNMTVLSR DFPWTFSLSM LYIDNPVGTG FSFTDHIQGY AIDEDDVAQD
     LYSALVQFFK LFPEYAKNDF YITGESYAGK YVPAIAYYIH SLNPVRRFKI RLKGIALGDA
     YTDPETIIGG YATFLYEVGL LDEQQRRHFR KQCRKCIKYI KEQEWMKAFE VLDELLDGDL
     TAGPSFFQNV TGCTNYYNIL QCTEPEDQSY FSKFLSLPQV RQAIHVGNRN FSDGAEVEKY
     LREDTVKSVK PWLAEIMNYY KVLIYNGQLD IIVAAALTER SLMTMDWKGS YAYRRTHKKI
     WKIFESDDEV AGYVRRVGKF HQVIVRGGGH ILPYDQPLRS FDMINRFIYD RGWEPYKL