CPXCR_HUMAN
ID CPXCR_HUMAN Reviewed; 301 AA.
AC Q8N123; B2R9F9; D3DTE7; Q96RS3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=CPX chromosomal region candidate gene 1 protein;
DE AltName: Full=Cancer/testis antigen 77;
DE Short=CT77;
GN Name=CPXCR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-3 AND HIS-131, AND TISSUE
RP SPECIFICITY.
RX PubMed=11499681; DOI=10.1007/s004390100518;
RA Braybrook C., Warry G., Howell G., Mandryko V., Arnason A., Bjornsson A.,
RA Ross M.T., Moore G.E., Stanier P.;
RT "Physical and transcriptional mapping of the X-linked cleft palate and
RT ankyloglossia (CPX) critical region.";
RL Hum. Genet. 108:537-545(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-3.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-3.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-3.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- TISSUE SPECIFICITY: Expressed in a variety of fetal tissues.
CC {ECO:0000269|PubMed:11499681}.
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DR EMBL; AF284767; AAK69720.1; -; mRNA.
DR EMBL; AK098646; BAC05363.1; -; mRNA.
DR EMBL; AK313768; BAG36506.1; -; mRNA.
DR EMBL; AL031116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471104; EAW98549.1; -; Genomic_DNA.
DR EMBL; CH471104; EAW98550.1; -; Genomic_DNA.
DR EMBL; CH471104; EAW98551.1; -; Genomic_DNA.
DR EMBL; BC027614; AAH27614.1; -; mRNA.
DR CCDS; CCDS14458.1; -.
DR RefSeq; NP_001171700.1; NM_001184771.1.
DR RefSeq; NP_149037.4; NM_033048.5.
DR AlphaFoldDB; Q8N123; -.
DR BioGRID; 119738; 5.
DR IntAct; Q8N123; 1.
DR MINT; Q8N123; -.
DR STRING; 9606.ENSP00000276127; -.
DR PhosphoSitePlus; Q8N123; -.
DR BioMuta; CPXCR1; -.
DR DMDM; 158706462; -.
DR MassIVE; Q8N123; -.
DR PaxDb; Q8N123; -.
DR PeptideAtlas; Q8N123; -.
DR PRIDE; Q8N123; -.
DR ProteomicsDB; 71523; -.
DR Antibodypedia; 14397; 141 antibodies from 28 providers.
DR DNASU; 53336; -.
DR Ensembl; ENST00000276127.9; ENSP00000276127.4; ENSG00000147183.10.
DR Ensembl; ENST00000373111.5; ENSP00000362203.1; ENSG00000147183.10.
DR Ensembl; ENST00000614120.1; ENSP00000484986.1; ENSG00000147183.10.
DR GeneID; 53336; -.
DR KEGG; hsa:53336; -.
DR MANE-Select; ENST00000276127.9; ENSP00000276127.4; NM_033048.6; NP_149037.5.
DR UCSC; uc004efc.5; human.
DR CTD; 53336; -.
DR DisGeNET; 53336; -.
DR GeneCards; CPXCR1; -.
DR HGNC; HGNC:2332; CPXCR1.
DR HPA; ENSG00000147183; Tissue enriched (testis).
DR MIM; 301055; gene.
DR neXtProt; NX_Q8N123; -.
DR OpenTargets; ENSG00000147183; -.
DR PharmGKB; PA26852; -.
DR VEuPathDB; HostDB:ENSG00000147183; -.
DR eggNOG; ENOG502TDNH; Eukaryota.
DR GeneTree; ENSGT00390000003732; -.
DR HOGENOM; CLU_924280_0_0_1; -.
DR InParanoid; Q8N123; -.
DR OMA; IPIPRKW; -.
DR OrthoDB; 1037339at2759; -.
DR PhylomeDB; Q8N123; -.
DR TreeFam; TF341435; -.
DR PathwayCommons; Q8N123; -.
DR SignaLink; Q8N123; -.
DR BioGRID-ORCS; 53336; 8 hits in 686 CRISPR screens.
DR GenomeRNAi; 53336; -.
DR Pharos; Q8N123; Tdark.
DR PRO; PR:Q8N123; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N123; protein.
DR Bgee; ENSG00000147183; Expressed in sperm and 16 other tissues.
DR Genevisible; Q8N123; HS.
DR InterPro; IPR039710; CPXCR1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR42213; PTHR42213; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..301
FT /note="CPX chromosomal region candidate gene 1 protein"
FT /id="PRO_0000305343"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 3
FT /note="Y -> S (in dbSNP:rs5940915)"
FT /evidence="ECO:0000269|PubMed:11499681,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.4"
FT /id="VAR_035218"
FT VARIANT 131
FT /note="R -> H (in dbSNP:rs5984611)"
FT /evidence="ECO:0000269|PubMed:11499681"
FT /id="VAR_035219"
SQ SEQUENCE 301 AA; 34727 MW; DB2A6AB3F225564B CRC64;
MSYPTKEGSD TAGNAHKNSE NEPPNDCSTD IESPSADPNM IYQVETNPIN REPGTATSQE
DVVPQAAENS ELETEIQKDQ REEDLKEELL LLQTPIPRKL VSHKPLNDRS RSHSGKVEMK
ANNFPINHKT RFRLSTSWRV PFINSHEIRS MILHLLCDRY FSQAAGCQNT MWVKRKYIAC
LYHPNSFTHH ERAITFRRPS RVHYYRPLTE RMTSGKFCKS TDTKGKCRFR AIVRSVLFVS
QIQIESIFNI KGFVDILTYI HTMNVMITNT NNGWKYFCPI CGRLFNTYSE LRQHSCSSSG
N
