CPXM2_HUMAN
ID CPXM2_HUMAN Reviewed; 756 AA.
AC Q8N436; B4E3Q2;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Inactive carboxypeptidase-like protein X2;
DE Flags: Precursor;
GN Name=CPXM2; Synonyms=CPX2; ORFNames=UNQ676/PRO1310;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-750.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-750.
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-750.
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-750.
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in cell-cell interactions.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase M14 family. {ECO:0000305}.
CC -!- CAUTION: Although related to peptidase M14 family, lacks the active
CC site residues and zinc-binding sites, suggesting that it has no
CC carboxypeptidase activity. {ECO:0000305}.
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DR EMBL; AY358565; AAQ88928.1; -; mRNA.
DR EMBL; AK304814; BAG65564.1; -; mRNA.
DR EMBL; AC009987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC068058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49279.1; -; Genomic_DNA.
DR EMBL; BC036789; AAH36789.2; -; mRNA.
DR EMBL; BC137492; AAI37493.1; -; mRNA.
DR EMBL; BC146862; AAI46863.1; -; mRNA.
DR CCDS; CCDS7637.1; -.
DR RefSeq; NP_937791.2; NM_198148.2.
DR AlphaFoldDB; Q8N436; -.
DR SMR; Q8N436; -.
DR BioGRID; 125646; 7.
DR STRING; 9606.ENSP00000241305; -.
DR MEROPS; M14.955; -.
DR GlyConnect; 1395; 6 N-Linked glycans (2 sites).
DR GlyGen; Q8N436; 7 sites, 5 N-linked glycans (2 sites), 1 O-linked glycan (2 sites).
DR iPTMnet; Q8N436; -.
DR PhosphoSitePlus; Q8N436; -.
DR BioMuta; CPXM2; -.
DR DMDM; 296439384; -.
DR jPOST; Q8N436; -.
DR MassIVE; Q8N436; -.
DR PaxDb; Q8N436; -.
DR PeptideAtlas; Q8N436; -.
DR PRIDE; Q8N436; -.
DR ProteomicsDB; 71876; -.
DR Antibodypedia; 32356; 128 antibodies from 30 providers.
DR DNASU; 119587; -.
DR Ensembl; ENST00000241305.4; ENSP00000241305.3; ENSG00000121898.13.
DR GeneID; 119587; -.
DR KEGG; hsa:119587; -.
DR MANE-Select; ENST00000241305.4; ENSP00000241305.3; NM_198148.3; NP_937791.2.
DR UCSC; uc001lhk.2; human.
DR CTD; 119587; -.
DR DisGeNET; 119587; -.
DR GeneCards; CPXM2; -.
DR HGNC; HGNC:26977; CPXM2.
DR HPA; ENSG00000121898; Tissue enhanced (choroid).
DR MIM; 617348; gene.
DR neXtProt; NX_Q8N436; -.
DR OpenTargets; ENSG00000121898; -.
DR PharmGKB; PA134866722; -.
DR VEuPathDB; HostDB:ENSG00000121898; -.
DR eggNOG; KOG2649; Eukaryota.
DR GeneTree; ENSGT00940000156414; -.
DR HOGENOM; CLU_006722_4_0_1; -.
DR InParanoid; Q8N436; -.
DR OMA; CPDKSPQ; -.
DR OrthoDB; 101221at2759; -.
DR PhylomeDB; Q8N436; -.
DR TreeFam; TF315592; -.
DR PathwayCommons; Q8N436; -.
DR BioGRID-ORCS; 119587; 7 hits in 1062 CRISPR screens.
DR ChiTaRS; CPXM2; human.
DR GenomeRNAi; 119587; -.
DR Pharos; Q8N436; Tbio.
DR PRO; PR:Q8N436; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8N436; protein.
DR Bgee; ENSG00000121898; Expressed in right coronary artery and 169 other tissues.
DR ExpressionAtlas; Q8N436; baseline and differential.
DR Genevisible; Q8N436; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006518; P:peptide metabolic process; IBA:GO_Central.
DR GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR CDD; cd00057; FA58C; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000834; Peptidase_M14.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF49464; SSF49464; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..756
FT /note="Inactive carboxypeptidase-like protein X2"
FT /id="PRO_0000004409"
FT DOMAIN 134..293
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT REGION 51..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 281
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 491
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 136..293
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT VARIANT 750
FT /note="Q -> R (in dbSNP:rs7088479)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.3"
FT /id="VAR_048603"
SQ SEQUENCE 756 AA; 85870 MW; 1A2F1A5BA7C1DCBE CRC64;
MSRPGTATPA LALVLLAVTL AGVGAQGAAL EDPDYYGQEI WSREPYYARP EPELETFSPP
LPAGPGEEWE RRPQEPRPPK RATKPKKAPK REKSAPEPPP PGKHSNKKVM RTKSSEKAAN
DDHSVRVARE DVRESCPPLG LETLKITDFQ LHASTVKRYG LGAHRGRLNI QAGINENDFY
DGAWCAGRND LQQWIEVDAR RLTRFTGVIT QGRNSLWLSD WVTSYKVMVS NDSHTWVTVK
NGSGDMIFEG NSEKEIPVLN ELPVPMVARY IRINPQSWFD NGSICMRMEI LGCPLPDPNN
YYHRRNEMTT TDDLDFKHHN YKEMRQLMKV VNEMCPNITR IYNIGKSHQG LKLYAVEISD
HPGEHEVGEP EFHYIAGAHG NEVLGRELLL LLVQFVCQEY LARNARIVHL VEETRIHVLP
SLNPDGYEKA YEGGSELGGW SLGRWTHDGI DINNNFPDLN TLLWEAEDRQ NVPRKVPNHY
IAIPEWFLSE NATVAAETRA VIAWMEKIPF VLGGNLQGGE LVVAYPYDLV RSPWKTQEHT
PTPDDHVFRW LAYSYASTHR LMTDARRRVC HTEDFQKEEG TVNGASWHTV AGSLNDFSYL
HTNCFELSIY VGCDKYPHES QLPEEWENNR ESLIVFMEQV HRGIKGLVRD SHGKGIPNAI
ISVEGINHDI RTANDGDYWR LLNPGEYVVT AKAEGFTAST KNCMVGYDMG ATRCDFTLSK
TNMARIREIM EKFGKQPVSL PARRLKLRGQ KRRQRG
