ID   CPXP_ECOL6              Reviewed;         166 AA.
AC   P0AE86; O65939; P32158;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Periplasmic protein CpxP;
DE   Flags: Precursor;
GN   Name=cpxP; OrderedLocusNames=c4865;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Acts as an accessory protein in the Cpx two-component
CC       envelope stress response system. Binds the periplasmic domain of sensor
CC       histidine kinase CpxA, inhibiting induction of the envelope stress
CC       response in the absence of inducer. Aids in combating extracytoplasmic
CC       protein-mediated toxicity. {ECO:0000250|UniProtKB:P0AE85}.
CC   -!- SUBUNIT: Homodimer. Interacts with the periplasmic domain of CpxA.
CC       {ECO:0000250|UniProtKB:P0AE85}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:P0AE85}.
CC   -!- SIMILARITY: Belongs to the CpxP/Spy family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN83293.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN83293.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001223800.1; NC_004431.1.
DR   AlphaFoldDB; P0AE86; -.
DR   SMR; P0AE86; -.
DR   STRING; 199310.c4865; -.
DR   EnsemblBacteria; AAN83293; AAN83293; c4865.
DR   GeneID; 66672178; -.
DR   KEGG; ecc:c4865; -.
DR   eggNOG; COG3678; Bacteria.
DR   HOGENOM; CLU_124352_2_1_6; -.
DR   OMA; NERMQEC; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd09916; CpxP_like; 1.
DR   InterPro; IPR012899; LTXXQ.
DR   Pfam; PF07813; LTXXQ; 1.
DR   PIRSF; PIRSF034445; CpxP_Spy; 1.
PE   3: Inferred from homology;
KW   Periplasm; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..166
FT                   /note="Periplasmic protein CpxP"
FT                   /id="PRO_0000043381"
SQ   SEQUENCE   166 AA;  18965 MW;  BD517D2D14D90209 CRC64;
     MRIVTAAVMA STLAVSSLSH AAEVGSGDNW HPGEELTQRS TQSHMFDGIS LTEHQRQQMR
     DLMQQARHEQ PPVNVSELET MHRLVTAENF DENAVRAQAE KMANEQIARQ VEMAKVRNQM
     YRLLTPEQQA VLNEKHQQRM EQLRDVTQWQ KSSSLKLLSS SNSRSQ