ID   CPXP_SHIFL              Reviewed;         166 AA.
AC   P0AE87; O65939; P32158;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Periplasmic protein CpxP;
DE   Flags: Precursor;
GN   Name=cpxP; OrderedLocusNames=SF3992, S3755;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Acts as an accessory protein in the Cpx two-component
CC       envelope stress response system. Binds the periplasmic domain of sensor
CC       histidine kinase CpxA, inhibiting induction of the envelope stress
CC       response in the absence of inducer. Aids in combating extracytoplasmic
CC       protein-mediated toxicity. {ECO:0000250|UniProtKB:P0AE85}.
CC   -!- SUBUNIT: Homodimer. Interacts with the periplasmic domain of CpxA.
CC       {ECO:0000250|UniProtKB:P0AE85}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:P0AE85}.
CC   -!- SIMILARITY: Belongs to the CpxP/Spy family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN45426.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP18774.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN45426.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP18774.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001223800.1; NZ_WPGW01000012.1.
DR   AlphaFoldDB; P0AE87; -.
DR   SMR; P0AE87; -.
DR   STRING; 198214.SF3992; -.
DR   EnsemblBacteria; AAN45426; AAN45426; SF3992.
DR   EnsemblBacteria; AAP18774; AAP18774; S3755.
DR   GeneID; 66672178; -.
DR   KEGG; sfx:S3755; -.
DR   PATRIC; fig|623.156.peg.2585; -.
DR   HOGENOM; CLU_124352_2_1_6; -.
DR   OrthoDB; 1720629at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   CDD; cd09916; CpxP_like; 1.
DR   InterPro; IPR012899; LTXXQ.
DR   Pfam; PF07813; LTXXQ; 1.
DR   PIRSF; PIRSF034445; CpxP_Spy; 1.
PE   3: Inferred from homology;
KW   Periplasm; Reference proteome; Signal; Stress response.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..166
FT                   /note="Periplasmic protein CpxP"
FT                   /id="PRO_0000043382"
SQ   SEQUENCE   166 AA;  18965 MW;  BD517D2D14D90209 CRC64;
     MRIVTAAVMA STLAVSSLSH AAEVGSGDNW HPGEELTQRS TQSHMFDGIS LTEHQRQQMR
     DLMQQARHEQ PPVNVSELET MHRLVTAENF DENAVRAQAE KMANEQIARQ VEMAKVRNQM
     YRLLTPEQQA VLNEKHQQRM EQLRDVTQWQ KSSSLKLLSS SNSRSQ