ID   CPXU_SINFN              Reviewed;         447 AA.
AC   P55540;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Cytochrome P450 BJ-4 homolog;
DE            EC=1.14.14.-;
GN   Name=cyp117A2; OrderedLocusNames=NGR_a02740; ORFNames=y4kV;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       They oxidize a variety of structurally unrelated compounds, including
CC       steroids, fatty acids, and xenobiotics.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; U00090; AAB91753.1; -; Genomic_DNA.
DR   PIR; T10876; T10876.
DR   RefSeq; NP_443951.1; NC_000914.2.
DR   RefSeq; WP_010875299.1; NC_000914.2.
DR   AlphaFoldDB; P55540; -.
DR   SMR; P55540; -.
DR   STRING; 394.NGR_a02740; -.
DR   EnsemblBacteria; AAB91753; AAB91753; NGR_a02740.
DR   KEGG; rhi:NGR_a02740; -.
DR   PATRIC; fig|394.7.peg.292; -.
DR   eggNOG; COG2124; Bacteria.
DR   HOGENOM; CLU_001570_5_1_5; -.
DR   OMA; RDRMYAM; -.
DR   OrthoDB; 520970at2; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00465; EP450IV.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..447
FT                   /note="Cytochrome P450 BJ-4 homolog"
FT                   /id="PRO_0000052310"
FT   BINDING         392
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   447 AA;  49855 MW;  55E4DB48438F2973 CRC64;
     MNVLLNPLNR RHRLRYDIPV MPGAFPLVGH LPAIVCDLPR LLRRAERTLG SHFWLDFGPA
     GHLMTCVDPH AFALLRHKDV SSALIEEIAP ELLGGTLVAQ DGGAHRQARD AIKAAFLPEG
     LTQAGIGDLF APVIRARVQA WRDRGDVTIL PETGDLMLKL IFTLMGVPAQ DLPGWHRKYR
     QLLQLIVAPS VDLPGLPLRR GRAARDWIDA QLRQFVRDAR AHAARTGLIN DMVSAFDRSD
     DALSDDLLVA NIRLLLLAGH DTTASTMAWM VIELARQPML WDALVEEAQR VGAVPTRHAD
     LEQCPVAEAL FRETLRVHPA TTLLPRRALQ ELQLGQRRIP AGTHLCIPLL HFSTSALLHE
     APDQFRLARW LQRTEPIRPV DMLQFGTGPH VCIGYHLVWL ELVQFSIALA LTMHKAGVRP
     LLLSGVEKGR RYYPTAHPSM TIRIGFS