CPXY_BACSU
ID CPXY_BACSU Reviewed; 410 AA.
AC O08469;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Cytochrome P450;
DE EC=1.14.-.-;
GN Name=cypA; Synonyms=CYP107J1, yrdE; OrderedLocusNames=BSU26740;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=9287000; DOI=10.1128/jb.179.17.5448-5457.1997;
RA Belitsky B.R., Gustafsson M.C.U., Sonenshein A.L., von Wachenfeldt C.;
RT "An lrp-like gene of Bacillus subtilis involved in branched-chain amino
RT acid transport.";
RL J. Bacteriol. 179:5448-5457(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA Duesterhoeft A., Ehrlich S.D.;
RT "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT operon reveals two new extracytoplasmic function RNA polymerase sigma
RT factors SigV and SigZ.";
RL Microbiology 143:2939-2943(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; Y11043; CAA71937.1; -; Genomic_DNA.
DR EMBL; U93876; AAB80898.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14615.1; -; Genomic_DNA.
DR PIR; E69611; E69611.
DR RefSeq; NP_390551.1; NC_000964.3.
DR RefSeq; WP_003229866.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; O08469; -.
DR SMR; O08469; -.
DR STRING; 224308.BSU26740; -.
DR PaxDb; O08469; -.
DR PRIDE; O08469; -.
DR EnsemblBacteria; CAB14615; CAB14615; BSU_26740.
DR GeneID; 937623; -.
DR KEGG; bsu:BSU26740; -.
DR PATRIC; fig|224308.179.peg.2904; -.
DR eggNOG; COG2124; Bacteria.
DR InParanoid; O08469; -.
DR OMA; QEMISTC; -.
DR PhylomeDB; O08469; -.
DR BioCyc; BSUB:BSU26740-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002397; Cyt_P450_B.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00359; BP450.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..410
FT /note="Cytochrome P450"
FT /id="PRO_0000052233"
FT BINDING 359
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 410 AA; 47385 MW; 035E98E58A4761AB CRC64;
MSSKEKKSVT ILTESQLSSR AFKDEAYEFY KELRKSQALY PLSLGALGKG WLISRYDDAI
HLLKNEKLKK NYENVFTAKE KRPALLKNEE TLTKHMLNSD PPDHNRLRTL VQKAFTHRMI
LQLEDKIQHI ADSLLDKVQP NKFMNLVDDY AFPLPIIVIS EMLGIPLEDR QKFRVWSQAI
IDFSDAPERL QENDHLLGEF VEYLESLVRK KRREPAGDLI SALIQAESEG TQLSTEELYS
MIMLLIVAGH ETTVNLITNM TYALMCHHDQ LEKLRQQPDL MNSAIEEALR FHSPVELTTI
RWTAEPFILH GQEIKRKDVI IISLASANRD EKIFPNADIF DIERKNNRHI AFGHGNHFCL
GAQLARLEAK IAISTLLRRC PNIQLKGEKK QMKWKGNFLM RALEELPISF
