ID   CQ050_HUMAN             Reviewed;         174 AA.
AC   Q8WW18; Q6Q621;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Uncharacterized protein C17orf50;
GN   Name=C17orf50;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Li H., Ke R., Zhong G., Shen C., Zhou G., Lin L., Yang S.;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       Q8WW18; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-12877892, EBI-11954519;
CC       Q8WW18; Q96Q77: CIB3; NbExp=3; IntAct=EBI-12877892, EBI-10292696;
CC       Q8WW18; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-12877892, EBI-11962928;
CC       Q8WW18; O76011: KRT34; NbExp=3; IntAct=EBI-12877892, EBI-1047093;
CC       Q8WW18; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-12877892, EBI-10172150;
CC       Q8WW18; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-12877892, EBI-10171774;
CC       Q8WW18; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-12877892, EBI-11956269;
CC       Q8WW18; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-12877892, EBI-11747707;
CC       Q8WW18; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-12877892, EBI-6427977;
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DR   EMBL; AY557347; AAS67921.1; -; mRNA.
DR   CCDS; CCDS42298.1; -.
DR   RefSeq; NP_660315.2; NM_145272.3.
DR   AlphaFoldDB; Q8WW18; -.
DR   BioGRID; 127018; 11.
DR   IntAct; Q8WW18; 9.
DR   STRING; 9606.ENSP00000475146; -.
DR   BioMuta; C17orf50; -.
DR   DMDM; 115502131; -.
DR   MassIVE; Q8WW18; -.
DR   PaxDb; Q8WW18; -.
DR   PeptideAtlas; Q8WW18; -.
DR   PRIDE; Q8WW18; -.
DR   Antibodypedia; 77192; 5 antibodies from 5 providers.
DR   DNASU; 146853; -.
DR   Ensembl; ENST00000605587.2; ENSP00000475146.1; ENSG00000270806.2.
DR   GeneID; 146853; -.
DR   KEGG; hsa:146853; -.
DR   MANE-Select; ENST00000605587.2; ENSP00000475146.1; NM_145272.4; NP_660315.2.
DR   UCSC; uc002hjx.4; human.
DR   CTD; 146853; -.
DR   GeneCards; C17orf50; -.
DR   HGNC; HGNC:29581; C17orf50.
DR   HPA; ENSG00000270806; Tissue enriched (testis).
DR   neXtProt; NX_Q8WW18; -.
DR   OpenTargets; ENSG00000270806; -.
DR   PharmGKB; PA142672233; -.
DR   VEuPathDB; HostDB:ENSG00000270806; -.
DR   eggNOG; ENOG502SXTN; Eukaryota.
DR   GeneTree; ENSGT00390000007830; -.
DR   HOGENOM; CLU_102789_0_0_1; -.
DR   InParanoid; Q8WW18; -.
DR   OMA; YVAHCVL; -.
DR   PhylomeDB; Q8WW18; -.
DR   TreeFam; TF337655; -.
DR   PathwayCommons; Q8WW18; -.
DR   SignaLink; Q8WW18; -.
DR   BioGRID-ORCS; 146853; 34 hits in 1029 CRISPR screens.
DR   ChiTaRS; C17orf50; human.
DR   GenomeRNAi; 146853; -.
DR   Pharos; Q8WW18; Tdark.
DR   PRO; PR:Q8WW18; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8WW18; protein.
DR   Bgee; ENSG00000270806; Expressed in left testis and 90 other tissues.
DR   ExpressionAtlas; Q8WW18; baseline and differential.
DR   Genevisible; Q8WW18; HS.
DR   InterPro; IPR029174; DUF4637.
DR   PANTHER; PTHR37878; PTHR37878; 1.
DR   Pfam; PF15470; DUF4637; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..174
FT                   /note="Uncharacterized protein C17orf50"
FT                   /id="PRO_0000251202"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         22
FT                   /note="D -> E (in dbSNP:rs4795087)"
FT                   /id="VAR_050899"
SQ   SEQUENCE   174 AA;  19346 MW;  DECB7ADE092596CE CRC64;
     MDKHGVKTPL WKKETEELRA EDAEQEEGKE GSEDEDEDNQ RPLEDSATEG EEPPRVAEEG
     EGRERRSVSY CPLRQESSTQ QVALLRRADS GFWGWLGPLA LLGGLTAPTD RKRSLPEEPC
     VLEIRRRPPR RGGCACCELL FCKKCRSLHS HPAYVAHCVL DHPDLGKAGA AGNS