CQ058_HUMAN
ID CQ058_HUMAN Reviewed; 339 AA.
AC Q2M2W7; A0A1B0GTI9; A8MQV2;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=UPF0450 protein C17orf58;
DE Flags: Precursor;
GN Name=C17orf58;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-339 (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 171-339 (ISOFORM 2).
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-339 (ISOFORM 1), AND VARIANT
RP VAL-334.
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2M2W7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2M2W7-2; Sequence=VSP_036597;
CC -!- SIMILARITY: Belongs to the UPF0450 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH36760.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI05125.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI12074.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC134407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK026583; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL556320; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC036760; AAH36760.1; ALT_INIT; mRNA.
DR EMBL; BC105124; AAI05125.1; ALT_INIT; mRNA.
DR EMBL; BC112073; AAI12074.1; ALT_INIT; mRNA.
DR RefSeq; NP_858041.2; NM_181655.3. [Q2M2W7-1]
DR RefSeq; NP_858042.2; NM_181656.4. [Q2M2W7-2]
DR AlphaFoldDB; Q2M2W7; -.
DR STRING; 9606.ENSP00000402020; -.
DR iPTMnet; Q2M2W7; -.
DR PhosphoSitePlus; Q2M2W7; -.
DR BioMuta; C17orf58; -.
DR DMDM; 215273993; -.
DR MassIVE; Q2M2W7; -.
DR PaxDb; Q2M2W7; -.
DR PeptideAtlas; Q2M2W7; -.
DR PRIDE; Q2M2W7; -.
DR ProteomicsDB; 61357; -. [Q2M2W7-1]
DR ProteomicsDB; 61358; -. [Q2M2W7-2]
DR Antibodypedia; 31734; 66 antibodies from 13 providers.
DR DNASU; 284018; -.
DR Ensembl; ENST00000580729.3; ENSP00000489720.1; ENSG00000186665.10. [Q2M2W7-1]
DR GeneID; 284018; -.
DR KEGG; hsa:284018; -.
DR MANE-Select; ENST00000580729.3; ENSP00000489720.1; NM_001382359.1; NP_001369288.1.
DR UCSC; uc002jgi.6; human. [Q2M2W7-1]
DR CTD; 284018; -.
DR DisGeNET; 284018; -.
DR GeneCards; C17orf58; -.
DR HGNC; HGNC:27568; C17orf58.
DR HPA; ENSG00000186665; Tissue enhanced (placenta).
DR neXtProt; NX_Q2M2W7; -.
DR OpenTargets; ENSG00000186665; -.
DR PharmGKB; PA142672241; -.
DR VEuPathDB; HostDB:ENSG00000186665; -.
DR eggNOG; ENOG502RZCW; Eukaryota.
DR GeneTree; ENSGT00390000002361; -.
DR HOGENOM; CLU_183146_0_0_1; -.
DR InParanoid; Q2M2W7; -.
DR OrthoDB; 1549076at2759; -.
DR PhylomeDB; Q2M2W7; -.
DR TreeFam; TF341123; -.
DR PathwayCommons; Q2M2W7; -.
DR BioGRID-ORCS; 284018; 92 hits in 1045 CRISPR screens.
DR GenomeRNAi; 284018; -.
DR Pharos; Q2M2W7; Tdark.
DR PRO; PR:Q2M2W7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q2M2W7; protein.
DR Bgee; ENSG00000186665; Expressed in synovial joint and 193 other tissues.
DR ExpressionAtlas; Q2M2W7; baseline and differential.
DR Genevisible; Q2M2W7; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR SUPFAM; SSF50242; SSF50242; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..339
FT /note="UPF0450 protein C17orf58"
FT /id="PRO_0000279445"
FT DOMAIN 193..338
FT /note="NTR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT REGION 17..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 193..267
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT DISULFID 197..271
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT DISULFID 208..338
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT VAR_SEQ 278..339
FT /note="SRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQ
FT IQGAIHTQCI -> IETDLNDAAYVLYTTVCNVGATARAVGRPAFFWERWGTMT (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3"
FT /id="VSP_036597"
FT VARIANT 334
FT /note="I -> V (in dbSNP:rs9891146)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030902"
SQ SEQUENCE 339 AA; 36985 MW; 42CF85F8625D3D0B CRC64;
MTARAFWLLC LIVGSSPEAP VAERKTSPPH SRKPDSRGCP SAEETPGPRA QPLLEAPQRP
RAAEVAPAAR AWPDPRRRKP PPPADNQASF REAARAPAGP PGPRLAQAEN RASPRREPAS
EDAPRRARSR ALRFPAARPP ALATEGSAGH AHPNRPRAAA LAPGPAPAPP PRFSLSFGLS
PPQRDAEPGA EPCARACRSD LDEREAFCES EFAVNGIVHD VDVLGAGIRL VTLLVDRDGL
YKMNRLYLTP DGFFFRVHML ALDSSSCNKP CPEFKPGSRY IVMGHIYHKR RQLPTALLQV
LRGRLRPGDG LLRSSSSYVK RFNRKREGQI QGAIHTQCI
