ID   CQ058_XENLA             Reviewed;         379 AA.
AC   A2BDC9; A0A1L8EUZ6;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=UPF0450 protein C17orf58 homolog;
DE   Flags: Precursor;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J;
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA   Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA   Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA   Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA   Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA   Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA   Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA   Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA   Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA   Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA   Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-379.
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UPF0450 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI30209.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=OCT63168.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM004482; OCT63168.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC130208; AAI30209.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001092147.1; NM_001098677.1.
DR   RefSeq; XP_018089386.1; XM_018233897.1.
DR   AlphaFoldDB; A2BDC9; -.
DR   STRING; 8355.A0A1L8EUZ6; -.
DR   GeneID; 100049720; -.
DR   KEGG; xla:100049720; -.
DR   CTD; 100049720; -.
DR   Xenbase; XB-GENE-6253947; c17orf58.L.
DR   OrthoDB; 1248778at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 100049720; Expressed in camera-type eye and 7 other tissues.
DR   Gene3D; 2.40.50.120; -; 1.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   SUPFAM; SSF50242; SSF50242; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..379
FT                   /note="UPF0450 protein C17orf58 homolog"
FT                   /id="PRO_0000294144"
FT   DOMAIN          234..378
FT                   /note="NTR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT   REGION          76..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        234..308
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT   DISULFID        238..312
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT   DISULFID        249..378
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
SQ   SEQUENCE   379 AA;  42420 MW;  05930BD9FE432668 CRC64;
     MIPALTVPLL FLCATSASPA AGRGVLVPPD PKSKLIPSTT KGTHAIAKPT PSQAALRHLM
     VPADNFGLEM LTDHQRTRAT HPQRQGQDLA LPDKTRAKTK VTLDNNTGPR KVNSLSNREA
     LAGAQPEGRN FIPSFFGNSK VHQDRSQLSS YFQLHTKSSS LTASQNLQGR KYSRNNDYGS
     MDHESNRPGK MNPHREEEVV SNSTKPAWVI NRQPSSVLFQ RPAFRKGFDN KEMCIAECHR
     DKDEREAYCN SDFAVNGIVQ DMESVGKESR LLTLLVSSDG LYKMNRLYIS PDGFFFKVKI
     LVTDTLNCHK PCLDFKPGVR YIIMGQIYHK RIIFPQAMQH LLGGRLRAGD GFIKSSSYVQ
     RFNRKRGRKV LAAAHSKCR