ID   CQ067_HUMAN             Reviewed;          90 AA.
AC   Q0P5P2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Uncharacterized protein C17orf67;
DE   Flags: Precursor;
GN   Name=C17orf67;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q0P5P2; A2RRN7: CADPS; NbExp=3; IntAct=EBI-10226540, EBI-10179719;
CC       Q0P5P2; Q9HD26: GOPC; NbExp=3; IntAct=EBI-10226540, EBI-349832;
CC       Q0P5P2; Q96CV9: OPTN; NbExp=3; IntAct=EBI-10226540, EBI-748974;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AC106858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC093905; AAH93905.1; -; mRNA.
DR   EMBL; BC093907; AAH93907.1; -; mRNA.
DR   CCDS; CCDS42364.2; -.
DR   RefSeq; NP_001078899.2; NM_001085430.2.
DR   AlphaFoldDB; Q0P5P2; -.
DR   BioGRID; 130843; 2.
DR   IntAct; Q0P5P2; 3.
DR   STRING; 9606.ENSP00000380959; -.
DR   iPTMnet; Q0P5P2; -.
DR   PhosphoSitePlus; Q0P5P2; -.
DR   BioMuta; C17orf67; -.
DR   DMDM; 238054264; -.
DR   PaxDb; Q0P5P2; -.
DR   PeptideAtlas; Q0P5P2; -.
DR   PRIDE; Q0P5P2; -.
DR   Antibodypedia; 52531; 8 antibodies from 6 providers.
DR   DNASU; 339210; -.
DR   Ensembl; ENST00000397861.7; ENSP00000380959.2; ENSG00000214226.9.
DR   GeneID; 339210; -.
DR   KEGG; hsa:339210; -.
DR   MANE-Select; ENST00000397861.7; ENSP00000380959.2; NM_001085430.4; NP_001078899.2.
DR   UCSC; uc002iuq.5; human.
DR   CTD; 339210; -.
DR   DisGeNET; 339210; -.
DR   GeneCards; C17orf67; -.
DR   HGNC; HGNC:27900; C17orf67.
DR   HPA; ENSG00000214226; Low tissue specificity.
DR   neXtProt; NX_Q0P5P2; -.
DR   OpenTargets; ENSG00000214226; -.
DR   PharmGKB; PA142672250; -.
DR   VEuPathDB; HostDB:ENSG00000214226; -.
DR   eggNOG; ENOG502S8D0; Eukaryota.
DR   GeneTree; ENSGT00390000006555; -.
DR   HOGENOM; CLU_169362_0_0_1; -.
DR   InParanoid; Q0P5P2; -.
DR   OMA; YMHHLLR; -.
DR   OrthoDB; 1578612at2759; -.
DR   PhylomeDB; Q0P5P2; -.
DR   TreeFam; TF354165; -.
DR   PathwayCommons; Q0P5P2; -.
DR   SignaLink; Q0P5P2; -.
DR   BioGRID-ORCS; 339210; 5 hits in 597 CRISPR screens.
DR   ChiTaRS; C17orf67; human.
DR   GenomeRNAi; 339210; -.
DR   Pharos; Q0P5P2; Tdark.
DR   PRO; PR:Q0P5P2; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q0P5P2; protein.
DR   Bgee; ENSG00000214226; Expressed in thymus and 130 other tissues.
DR   Genevisible; Q0P5P2; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027870; DUF4543.
DR   Pfam; PF15076; DUF4543; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..90
FT                   /note="Uncharacterized protein C17orf67"
FT                   /id="PRO_0000287179"
FT   REGION          28..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   90 AA;  10670 MW;  6354F62529C9F16C CRC64;
     MKTLPVLVLS LTLLTVFSET SPILTEKQAK QLLRSRRQDR PSKPGFPDEP MREYMHHLLA
     LEHRAEEQFL EHWLNPHCKP HCDRNRIHPV