CQ080_MOUSE
ID CQ080_MOUSE Reviewed; 558 AA.
AC Q6PIX9; Q3UTJ1; Q80UV5; Q9CYN0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 3.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Uncharacterized protein C17orf80 homolog;
GN Name=D11Wsu47e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Brain cortex, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Czech II, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PIX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PIX9-2; Sequence=VSP_024575;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB30780.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK017508; BAB30780.1; ALT_SEQ; mRNA.
DR EMBL; AK139389; BAE23989.1; -; mRNA.
DR EMBL; AK171307; BAE42383.1; -; mRNA.
DR EMBL; AL603706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026908; AAH26908.2; -; mRNA.
DR EMBL; BC048942; AAH48942.1; -; mRNA.
DR CCDS; CCDS48976.1; -. [Q6PIX9-1]
DR RefSeq; NP_808445.2; NM_177777.5. [Q6PIX9-1]
DR RefSeq; XP_006533536.1; XM_006533473.2.
DR RefSeq; XP_011247361.1; XM_011249059.2. [Q6PIX9-1]
DR RefSeq; XP_017170063.1; XM_017314574.1. [Q6PIX9-2]
DR RefSeq; XP_017170064.1; XM_017314575.1. [Q6PIX9-2]
DR RefSeq; XP_017170065.1; XM_017314576.1. [Q6PIX9-2]
DR AlphaFoldDB; Q6PIX9; -.
DR STRING; 10090.ENSMUSP00000042025; -.
DR iPTMnet; Q6PIX9; -.
DR PhosphoSitePlus; Q6PIX9; -.
DR EPD; Q6PIX9; -.
DR MaxQB; Q6PIX9; -.
DR PaxDb; Q6PIX9; -.
DR PeptideAtlas; Q6PIX9; -.
DR PRIDE; Q6PIX9; -.
DR ProteomicsDB; 284163; -. [Q6PIX9-1]
DR ProteomicsDB; 284164; -. [Q6PIX9-2]
DR Antibodypedia; 2478; 79 antibodies from 18 providers.
DR Ensembl; ENSMUST00000042227; ENSMUSP00000042025; ENSMUSG00000041623. [Q6PIX9-1]
DR Ensembl; ENSMUST00000106621; ENSMUSP00000102232; ENSMUSG00000041623. [Q6PIX9-1]
DR GeneID; 276852; -.
DR KEGG; mmu:276852; -.
DR UCSC; uc007mev.1; mouse. [Q6PIX9-1]
DR CTD; 276852; -.
DR MGI; MGI:106356; D11Wsu47e.
DR VEuPathDB; HostDB:ENSMUSG00000041623; -.
DR eggNOG; KOG4092; Eukaryota.
DR GeneTree; ENSGT00510000049019; -.
DR HOGENOM; CLU_037702_0_0_1; -.
DR InParanoid; Q6PIX9; -.
DR OMA; GSTHEKF; -.
DR OrthoDB; 1133806at2759; -.
DR PhylomeDB; Q6PIX9; -.
DR TreeFam; TF324369; -.
DR BioGRID-ORCS; 276852; 3 hits in 72 CRISPR screens.
DR ChiTaRS; D11Wsu47e; mouse.
DR PRO; PR:Q6PIX9; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6PIX9; protein.
DR Bgee; ENSMUSG00000041623; Expressed in seminiferous tubule of testis and 165 other tissues.
DR ExpressionAtlas; Q6PIX9; baseline and differential.
DR Genevisible; Q6PIX9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR037694; C17orf80.
DR PANTHER; PTHR16270; PTHR16270; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..558
FT /note="Uncharacterized protein C17orf80 homolog"
FT /id="PRO_0000284613"
FT TOPO_DOM 1..527
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 549..558
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 29..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 552..558
FT /note="KLQHWRK -> SLTEQRLASLHSQGGLSTSGPPASILNANRNQTLDAY (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024575"
FT CONFLICT 225
FT /note="R -> H (in Ref. 3; AAH26908)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="G -> D (in Ref. 3; AAH26908)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="T -> A (in Ref. 3; AAH26908)"
FT /evidence="ECO:0000305"
FT CONFLICT 379
FT /note="I -> V (in Ref. 3; AAH26908)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="G -> E (in Ref. 3; AAH26908)"
FT /evidence="ECO:0000305"
FT CONFLICT 498
FT /note="T -> A (in Ref. 3; AAH26908)"
FT /evidence="ECO:0000305"
FT CONFLICT 555
FT /note="H -> R (in Ref. 3; AAH26908)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 558 AA; 60276 MW; 173C077E16B42AB9 CRC64;
MGAAEPRMEV CPYCKKPFKR LKSHLPHCKM RGPSISADQN VSQSKPAALA QKEKSPTRDL
TRAKEKELEV DRPKRAVKAE TSRASWTAAA SPLPEGILGS VRITKAEGEN KDQNQFSFQA
LSQAKPEVTL QRVTTPWSPA SDATSPKREL TQDVSESKGS PCPSETEAPS LVSSVEPFLA
NQDRKYSSTQ PHANPATSVG LKLGTVDPQR QKLRVKLLDV PLSDRHSPKS GSHGVQRVTP
SVLSREEGSQ DGGHLLGVSA HPGNTKTQKS ESLLLGLHTG LLGKAPVREH QELGLGMELS
QSKGNTENRM SVTNVQEGAG LGQGGKDPIT ATKAKPHTAL ELRNVFMPES GNQSLTSPAV
TSTPEENAQF CGQSHVPAIT LSVGSVRDVL EPTSFYQPHT AQAGHCLMSY SAQYPVPKTF
VGHVAAVTSG APPRSVGLEW FPELYPAYVG LGVLPRRPPP WSLAAQVPPL PTLQGRSVSK
VPWWGRSSAD SRSLEPLTLT TSSLPLMRLL GAVHKGWVQC NTTIKKSGVG GLTMLFAGYF
ILCCNWSFKH LKLQHWRK
