ID   CQ62_CONCB              Reviewed;          87 AA.
AC   V5V9Y7;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin Ca6.2 {ECO:0000303|PubMed:24126141};
DE   Flags: Precursor;
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=24126141; DOI=10.1074/mcp.m113.028647;
RA   Lu A., Yang L., Xu S., Wang C.;
RT   "Various conotoxin diversifications revealed by a venomic study of Conus
RT   flavidus.";
RL   Mol. Cell. Proteomics 13:105-118(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24126141}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:24126141}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin Q superfamily. {ECO:0000305}.
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DR   EMBL; KC582372; AHB89645.1; -; mRNA.
DR   AlphaFoldDB; V5V9Y7; -.
DR   SMR; V5V9Y7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..52
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000448848"
FT   CHAIN           53..87
FT                   /note="Conotoxin Ca6.2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5004741703"
FT   DISULFID        55..64
FT                   /evidence="ECO:0000305"
FT   DISULFID        58..70
FT                   /evidence="ECO:0000305"
FT   DISULFID        63..84
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   87 AA;  9531 MW;  F64FA2E040F634A6 CRC64;
     MHTLEMLLLV LLLVPLAPGE GDGQAVGGDR NPSEARRAYK RLLQRPARRM DRGGCTPCGP
     NLCCSEEFRC GTSTHHQTYG EPACLSY