ID   CQG3_CONFL              Reviewed;          76 AA.
AC   V5V893;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Conotoxin Fla16d {ECO:0000303|PubMed:24126141};
DE   AltName: Full=Conotoxin Fla16.1 {ECO:0000303|PubMed:24126141};
DE   Contains:
DE     RecName: Full=Conotoxin fla16a {ECO:0000303|PubMed:24126141};
DE   Contains:
DE     RecName: Full=Conotoxin fla16b {ECO:0000303|PubMed:24126141};
DE   Contains:
DE     RecName: Full=Conotoxin fla16c {ECO:0000303|PubMed:24126141};
DE   Flags: Precursor;
OS   Conus flavidus (Yellow Pacific cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus.
OX   NCBI_TaxID=101302;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 49-72, MASS SPECTROMETRY,
RP   AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=24126141; DOI=10.1074/mcp.m113.028647;
RA   Lu A., Yang L., Xu S., Wang C.;
RT   "Various conotoxin diversifications revealed by a venomic study of Conus
RT   flavidus.";
RL   Mol. Cell. Proteomics 13:105-118(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24126141}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:24126141}.
CC   -!- DOMAIN: The cysteine framework is XVI (C-C-CC). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: [Conotoxin fla16a]: Mass=2625.1; Method=Unknown;
CC       Note=Monoisotopic mass.; Evidence={ECO:0000269|PubMed:24126141};
CC   -!- MASS SPECTROMETRY: [Conotoxin fla16b]: Mass=2696.1; Method=Unknown;
CC       Note=Monoisotopic mass.; Evidence={ECO:0000269|PubMed:24126141};
CC   -!- MASS SPECTROMETRY: [Conotoxin fla16c]: Mass=2825.2; Method=Unknown;
CC       Note=Monoisotopic mass.; Evidence={ECO:0000269|PubMed:24126141};
CC   -!- MASS SPECTROMETRY: [Conotoxin Fla16d]: Mass=2988.2; Method=Unknown;
CC       Note=Monoisotopic mass.; Evidence={ECO:0000269|PubMed:24126141};
CC   -!- SIMILARITY: Belongs to the conotoxin Q superfamily. {ECO:0000305}.
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DR   EMBL; KC582363; AHB89636.1; -; mRNA.
DR   AlphaFoldDB; V5V893; -.
DR   SMR; V5V893; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..48
FT                   /evidence="ECO:0000305|PubMed:24126141"
FT                   /id="PRO_0000448843"
FT   PEPTIDE         49..72
FT                   /note="Conotoxin Fla16d"
FT                   /evidence="ECO:0000269|PubMed:24126141"
FT                   /id="PRO_5004741715"
FT   PEPTIDE         49..71
FT                   /note="Conotoxin fla16c"
FT                   /evidence="ECO:0000269|PubMed:24126141"
FT                   /id="PRO_0000448844"
FT   PEPTIDE         49..70
FT                   /note="Conotoxin fla16b"
FT                   /evidence="ECO:0000269|PubMed:24126141"
FT                   /id="PRO_0000448845"
FT   PEPTIDE         49..69
FT                   /note="Conotoxin fla16a"
FT                   /evidence="ECO:0000269|PubMed:24126141"
FT                   /id="PRO_0000448846"
FT   PROPEP          73..76
FT                   /evidence="ECO:0000305|PubMed:24126141"
FT                   /id="PRO_0000448847"
FT   DISULFID        55..64
FT                   /evidence="ECO:0000250|UniProtKB:P0DJC3"
FT   DISULFID        58..63
FT                   /evidence="ECO:0000250|UniProtKB:P0DJC3"
SQ   SEQUENCE   76 AA;  8651 MW;  BB5756BA8CF93087 CRC64;
     MHTLEMLLLL LLLLPLALGE GDGQAVAGDR NPSEARSTHE HFLQRLIRLI HGSDCQPCGQ
     YVCCPPWKYA EYRRFT