CR021_HUMAN
ID CR021_HUMAN Reviewed; 220 AA.
AC Q32NC0; Q6GW03; Q9BXV6; Q9BXW2;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=UPF0711 protein C18orf21;
DE AltName: Full=HBV X-transactivated gene 13 protein;
DE AltName: Full=HBV XAg-transactivated protein 13;
GN Name=C18orf21; Synonyms=XTP13; ORFNames=PNAS-124, PNAS-131;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ALA-132.
RA Cheng J., Liu Y., Hong Y., Wang J.-J., Yang Q.;
RT "Screening and cloning of the target genes transactivated by hepatitis B
RT virus X protein by microarray assay.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ALA-132.
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-220 (ISOFORM 1).
RC TISSUE=Promyelocytic leukemia;
RA Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W.,
RA Yang H., Zhao Z.-L.;
RT "Human acute promyelocytic leukemia cell line NB4's
RT apoptosis/differentiation related genes.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126; THR-130 AND THR-139, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q32NC0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q32NC0-2; Sequence=VSP_055184;
CC -!- SIMILARITY: Belongs to the UPF0711 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK07541.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAK07547.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY631401; AAT51696.1; -; mRNA.
DR EMBL; BC025950; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC108730; AAI08731.1; -; mRNA.
DR EMBL; BC119765; AAI19766.1; -; mRNA.
DR EMBL; BC119766; AAI19767.1; -; mRNA.
DR EMBL; AF277182; AAK07541.1; ALT_INIT; mRNA.
DR EMBL; AF277189; AAK07547.1; ALT_SEQ; mRNA.
DR CCDS; CCDS11916.2; -. [Q32NC0-1]
DR CCDS; CCDS56064.1; -. [Q32NC0-2]
DR RefSeq; NP_001188403.1; NM_001201474.1. [Q32NC0-2]
DR RefSeq; NP_001188404.1; NM_001201475.1. [Q32NC0-2]
DR RefSeq; NP_113634.3; NM_031446.4. [Q32NC0-1]
DR AlphaFoldDB; Q32NC0; -.
DR BioGRID; 123699; 172.
DR IntAct; Q32NC0; 29.
DR STRING; 9606.ENSP00000465517; -.
DR iPTMnet; Q32NC0; -.
DR PhosphoSitePlus; Q32NC0; -.
DR BioMuta; C18orf21; -.
DR DMDM; 121942208; -.
DR EPD; Q32NC0; -.
DR jPOST; Q32NC0; -.
DR MassIVE; Q32NC0; -.
DR MaxQB; Q32NC0; -.
DR PaxDb; Q32NC0; -.
DR PeptideAtlas; Q32NC0; -.
DR PRIDE; Q32NC0; -.
DR ProteomicsDB; 61619; -. [Q32NC0-1]
DR Antibodypedia; 54637; 25 antibodies from 11 providers.
DR DNASU; 83608; -.
DR Ensembl; ENST00000333234.5; ENSP00000329492.5; ENSG00000141428.17. [Q32NC0-2]
DR Ensembl; ENST00000592875.6; ENSP00000465517.1; ENSG00000141428.17. [Q32NC0-1]
DR Ensembl; ENST00000610527.4; ENSP00000480486.1; ENSG00000141428.17. [Q32NC0-2]
DR GeneID; 83608; -.
DR KEGG; hsa:83608; -.
DR MANE-Select; ENST00000592875.6; ENSP00000465517.1; NM_031446.5; NP_113634.3.
DR UCSC; uc002kzc.4; human. [Q32NC0-1]
DR CTD; 83608; -.
DR DisGeNET; 83608; -.
DR GeneCards; C18orf21; -.
DR HGNC; HGNC:28802; C18orf21.
DR HPA; ENSG00000141428; Low tissue specificity.
DR neXtProt; NX_Q32NC0; -.
DR OpenTargets; ENSG00000141428; -.
DR PharmGKB; PA134888949; -.
DR VEuPathDB; HostDB:ENSG00000141428; -.
DR eggNOG; ENOG502S2A1; Eukaryota.
DR GeneTree; ENSGT00390000013383; -.
DR HOGENOM; CLU_110760_0_0_1; -.
DR InParanoid; Q32NC0; -.
DR OMA; HKGVNRD; -.
DR OrthoDB; 1377101at2759; -.
DR PhylomeDB; Q32NC0; -.
DR PathwayCommons; Q32NC0; -.
DR SignaLink; Q32NC0; -.
DR BioGRID-ORCS; 83608; 303 hits in 1027 CRISPR screens.
DR GenomeRNAi; 83608; -.
DR Pharos; Q32NC0; Tdark.
DR PRO; PR:Q32NC0; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q32NC0; protein.
DR Bgee; ENSG00000141428; Expressed in tibialis anterior and 186 other tissues.
DR ExpressionAtlas; Q32NC0; baseline and differential.
DR Genevisible; Q32NC0; HS.
DR InterPro; IPR029779; DUF4674.
DR PANTHER; PTHR31402; PTHR31402; 1.
DR Pfam; PF15719; DUF4674; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..220
FT /note="UPF0711 protein C18orf21"
FT /id="PRO_0000279448"
FT REGION 117..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 126
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 130
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 139
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 1..88
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_055184"
FT VARIANT 132
FT /note="T -> A (in dbSNP:rs2276314)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_030903"
FT CONFLICT 212
FT /note="S -> F (in Ref. 2; AAK07541)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 220 AA; 24827 MW; 3BB72C83F47F14EF CRC64;
MRQKHYLEAA ARGLHDSCPG QARYLLWAYT SSHDDKSTFE ETCPYCFQLL VLDNSRVRLK
PKARLTPKIQ KLLNREARNY TLSFKEAKMV KKFKDSKSVL LITCKTCNRT VKHHGKSRSF
VSTLKSNPAT PTSKLSLKTP ERRTANPNHD MSGSKGKSPA SVFRTPTSGQ SVSTCSSKNT
SKTKKHFSQL KMLLSQNESQ KIPKVDFRNF LSSLKGGLLK
