CR025_HUMAN
ID CR025_HUMAN Reviewed; 404 AA.
AC Q96B23; A8K123; A8KAB6; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Uncharacterized protein C18orf25;
DE AltName: Full=ARKadia-like protein 1 {ECO:0000303|PubMed:15722956};
GN Name=C18orf25 {ECO:0000312|HGNC:HGNC:28172};
GN Synonyms=ARKL1 {ECO:0000303|PubMed:15722956};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15722956; DOI=10.1097/00041444-200503000-00007;
RA Pickard B.S., Malloy M.P., Clark L., Lehellard S., Ewald H.L., Mors O.,
RA Porteous D.J., Blackwood D.H., Muir W.J.;
RT "Candidate psychiatric illness genes identified in patients with
RT pericentric inversions of chromosome 18.";
RL Psychiatr. Genet. 15:37-44(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ALA-314
RP DEL.
RC TISSUE=Brain, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lymph node, and Skeletal muscle;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327; SER-328 AND SER-330, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-143; SER-145;
RP SER-327; SER-328 AND SER-330, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66 AND SER-67, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [16]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-347, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [17]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-358, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q96B23; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-742108, EBI-742054;
CC Q96B23; Q96N16: JAKMIP1; NbExp=3; IntAct=EBI-742108, EBI-2680803;
CC Q96B23; Q96EZ8: MCRS1; NbExp=5; IntAct=EBI-742108, EBI-348259;
CC Q96B23; P78317: RNF4; NbExp=3; IntAct=EBI-742108, EBI-2340927;
CC Q96B23; P63165: SUMO1; NbExp=7; IntAct=EBI-742108, EBI-80140;
CC Q96B23; G2XKQ0: SUMO1P1; NbExp=3; IntAct=EBI-742108, EBI-10175576;
CC Q96B23; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-742108, EBI-529518;
CC Q96B23; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-742108, EBI-10180829;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96B23-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96B23-2; Sequence=VSP_014753;
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DR EMBL; BK005125; DAA05329.1; -; mRNA.
DR EMBL; AK289738; BAF82427.1; -; mRNA.
DR EMBL; AK292981; BAF85670.1; -; mRNA.
DR EMBL; AL713661; CAD28470.1; -; mRNA.
DR EMBL; AL832027; CAD89920.1; -; mRNA.
DR EMBL; BX640683; CAE45812.1; -; mRNA.
DR EMBL; AC021763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC118647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF573673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471088; EAX01472.1; -; Genomic_DNA.
DR EMBL; CH471088; EAX01473.1; -; Genomic_DNA.
DR EMBL; BC016149; AAH16149.1; -; mRNA.
DR EMBL; BC084579; AAH84579.1; -; mRNA.
DR CCDS; CCDS42430.1; -. [Q96B23-1]
DR CCDS; CCDS42431.1; -. [Q96B23-2]
DR RefSeq; NP_001008240.1; NM_001008239.2. [Q96B23-2]
DR RefSeq; NP_659492.1; NM_145055.3. [Q96B23-1]
DR RefSeq; XP_011524124.1; XM_011525822.1. [Q96B23-1]
DR RefSeq; XP_016881044.1; XM_017025555.1. [Q96B23-2]
DR AlphaFoldDB; Q96B23; -.
DR BioGRID; 127053; 97.
DR IntAct; Q96B23; 40.
DR MINT; Q96B23; -.
DR STRING; 9606.ENSP00000481626; -.
DR GlyGen; Q96B23; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96B23; -.
DR PhosphoSitePlus; Q96B23; -.
DR BioMuta; C18orf25; -.
DR DMDM; 209572602; -.
DR EPD; Q96B23; -.
DR jPOST; Q96B23; -.
DR MassIVE; Q96B23; -.
DR MaxQB; Q96B23; -.
DR PaxDb; Q96B23; -.
DR PeptideAtlas; Q96B23; -.
DR PRIDE; Q96B23; -.
DR ProteomicsDB; 76036; -. [Q96B23-1]
DR ProteomicsDB; 76037; -. [Q96B23-2]
DR Antibodypedia; 22461; 114 antibodies from 17 providers.
DR DNASU; 147339; -.
DR Ensembl; ENST00000615052.5; ENSP00000481626.1; ENSG00000152242.11. [Q96B23-1]
DR Ensembl; ENST00000619301.4; ENSP00000480074.1; ENSG00000152242.11. [Q96B23-2]
DR GeneID; 147339; -.
DR KEGG; hsa:147339; -.
DR MANE-Select; ENST00000615052.5; ENSP00000481626.1; NM_145055.5; NP_659492.1.
DR UCSC; uc032hdb.2; human.
DR UCSC; uc032hdc.2; human. [Q96B23-1]
DR CTD; 147339; -.
DR DisGeNET; 147339; -.
DR GeneCards; C18orf25; -.
DR HGNC; HGNC:28172; C18orf25.
DR HPA; ENSG00000152242; Low tissue specificity.
DR neXtProt; NX_Q96B23; -.
DR OpenTargets; ENSG00000152242; -.
DR PharmGKB; PA134919240; -.
DR VEuPathDB; HostDB:ENSG00000152242; -.
DR eggNOG; ENOG502QUC3; Eukaryota.
DR GeneTree; ENSGT00390000016167; -.
DR HOGENOM; CLU_056953_0_0_1; -.
DR InParanoid; Q96B23; -.
DR OMA; PHYDISD; -.
DR OrthoDB; 1237164at2759; -.
DR PhylomeDB; Q96B23; -.
DR TreeFam; TF351299; -.
DR PathwayCommons; Q96B23; -.
DR SignaLink; Q96B23; -.
DR BioGRID-ORCS; 147339; 8 hits in 1042 CRISPR screens.
DR ChiTaRS; C18orf25; human.
DR GenomeRNAi; 147339; -.
DR Pharos; Q96B23; Tdark.
DR PRO; PR:Q96B23; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q96B23; protein.
DR Bgee; ENSG00000152242; Expressed in buccal mucosa cell and 183 other tissues.
DR ExpressionAtlas; Q96B23; baseline and differential.
DR Genevisible; Q96B23; HS.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR029306; RNF111_N.
DR Pfam; PF15303; RNF111_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Methylation;
KW Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..404
FT /note="Uncharacterized protein C18orf25"
FT /id="PRO_0000079312"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..200
FT /evidence="ECO:0000255"
FT COMPBIAS 1..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 66
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BH50"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 328
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 330
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 347
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CROSSLNK 358
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 239..299
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:17974005"
FT /id="VSP_014753"
FT VARIANT 314
FT /note="Missing"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_080245"
FT CONFLICT 233
FT /note="I -> V (in Ref. 3; CAD89920)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="N -> S (in Ref. 3; CAE45812)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 43395 MW; 9A3DC655FE41BA7E CRC64;
MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST VISSMPCLLM
ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS GHLADSDTLS SAEENEPSQA
ETAVEGDPSG VSGATVGRKS RRSRSESETS TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK
ERIRLLRQKR EAAARKKYNL LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPDG
PPVVAHYDMS DTNSDPEVVN VDNLLAAAVV QEHSNSVGGQ DTGATWRTSG LLEELNAEAG
HLDPGFLASD KTSAGNAPLN EEINIASSDS EVEIVGVQEH ARCVHPRGGV IQSVSSWKHG
SGTQYVSTRQ TQSWTAVTPQ QTWASPAEVV DLTLDEDSRR KYLL
