CR025_MOUSE
ID CR025_MOUSE Reviewed; 245 AA.
AC Q8BH50; Q3TQ72; Q8BU43;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Uncharacterized protein C18orf25 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=15722956; DOI=10.1097/00041444-200503000-00007;
RA Pickard B.S., Malloy M.P., Clark L., Lehellard S., Ewald H.L., Mors O.,
RA Porteous D.J., Blackwood D.H., Muir W.J.;
RT "Candidate psychiatric illness genes identified in patients with
RT pericentric inversions of chromosome 18.";
RL Psychiatr. Genet. 15:37-44(2005).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-145 AND SER-147, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BH50-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BH50-2; Sequence=VSP_014754, VSP_014755;
CC -!- TISSUE SPECIFICITY: Detected in brain, liver, lung, kidney, heart,
CC spleen, skeletal muscle and spinal cord. {ECO:0000269|PubMed:15722956}.
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DR EMBL; AK033209; BAC28197.1; -; mRNA.
DR EMBL; AK046785; BAC32868.1; -; mRNA.
DR EMBL; AK087799; BAC40007.1; -; mRNA.
DR EMBL; AK163840; BAE37513.1; -; mRNA.
DR RefSeq; NP_848785.2; NM_178670.3.
DR AlphaFoldDB; Q8BH50; -.
DR SMR; Q8BH50; -.
DR BioGRID; 229298; 9.
DR STRING; 10090.ENSMUSP00000074225; -.
DR iPTMnet; Q8BH50; -.
DR PhosphoSitePlus; Q8BH50; -.
DR EPD; Q8BH50; -.
DR MaxQB; Q8BH50; -.
DR PaxDb; Q8BH50; -.
DR PRIDE; Q8BH50; -.
DR DNASU; 212163; -.
DR GeneID; 212163; -.
DR KEGG; mmu:212163; -.
DR UCSC; uc008frq.1; mouse. [Q8BH50-1]
DR MGI; MGI:2444951; 8030462N17Rik.
DR eggNOG; ENOG502QUC3; Eukaryota.
DR InParanoid; Q8BH50; -.
DR OrthoDB; 1237164at2759; -.
DR PhylomeDB; Q8BH50; -.
DR BioGRID-ORCS; 212163; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q8BH50; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BH50; protein.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR029306; RNF111_N.
DR Pfam; PF15303; RNF111_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..245
FT /note="Uncharacterized protein C18orf25 homolog"
FT /id="PRO_0000079313"
FT REGION 1..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..200
FT /evidence="ECO:0000255"
FT COMPBIAS 24..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 66
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96B23"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96B23"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 160..162
FT /note="SSD -> LQR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014754"
FT VAR_SEQ 163..245
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014755"
SQ SEQUENCE 245 AA; 26446 MW; 4BFF251349BA3C8E CRC64;
MKMEEAVGKV EELIESAAPP KASEQETAKE EDGSVELESQ VQKDGVADST VLSSMPCLLM
ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS GHLADSDTLS SVEENEPSQA
ETTVEGDTSG VSGATVGRKS RRSRSESETS TMAAKKNRQS SDKQNGRVTK VKGHRSQKHK
ERIRLLRQKR EAAARKKYNL LQDSSTSDSD LTCDSSTSSS DDDDEVSGSS KTITAEIPGR
GCFLN
