CR032_HUMAN
ID CR032_HUMAN Reviewed; 76 AA.
AC Q8TCD1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=UPF0729 protein C18orf32;
DE AltName: Full=Putative NF-kappa-B-activating protein 200;
GN Name=C18orf32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND FUNCTION.
RC TISSUE=Lung;
RX PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y.,
RA Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.;
RT "Large-scale identification and characterization of human genes that
RT activate NF-kappaB and MAPK signaling pathways.";
RL Oncogene 22:3307-3318(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, INTERACTION WITH DERL1 AND AMFR, AND DEGRADATION.
RX PubMed=29275994; DOI=10.1016/j.devcel.2017.11.020;
RA Bersuker K., Peterson C.W.H., To M., Sahl S.J., Savikhin V., Grossman E.A.,
RA Nomura D.K., Olzmann J.A.;
RT "A Proximity Labeling Strategy Provides Insights into the Composition and
RT Dynamics of Lipid Droplet Proteomes.";
RL Dev. Cell 44:97-112(2018).
CC -!- FUNCTION: May activate the NF-kappa-B signaling pathway.
CC {ECO:0000269|PubMed:12761501}.
CC -!- SUBUNIT: Interacts with DERL1 and AMFR. {ECO:0000269|PubMed:29275994}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:29275994}. Lipid droplet
CC {ECO:0000269|PubMed:29275994}.
CC -!- PTM: Undergoes ER-associated degradation (ERAD).
CC {ECO:0000269|PubMed:29275994}.
CC -!- SIMILARITY: Belongs to the UPF0729 family. {ECO:0000305}.
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DR EMBL; AB097012; BAC77365.1; -; mRNA.
DR EMBL; AK291882; BAF84571.1; -; mRNA.
DR EMBL; BC022357; AAH22357.1; -; mRNA.
DR EMBL; BC093004; AAH93004.1; -; mRNA.
DR CCDS; CCDS32831.1; -.
DR RefSeq; NP_001030177.1; NM_001035005.3.
DR RefSeq; NP_001186275.1; NM_001199346.1.
DR AlphaFoldDB; Q8TCD1; -.
DR BioGRID; 139005; 12.
DR IntAct; Q8TCD1; 7.
DR MINT; Q8TCD1; -.
DR iPTMnet; Q8TCD1; -.
DR PhosphoSitePlus; Q8TCD1; -.
DR BioMuta; C18orf32; -.
DR EPD; Q8TCD1; -.
DR jPOST; Q8TCD1; -.
DR MassIVE; Q8TCD1; -.
DR MaxQB; Q8TCD1; -.
DR PaxDb; Q8TCD1; -.
DR PeptideAtlas; Q8TCD1; -.
DR PRIDE; Q8TCD1; -.
DR ProteomicsDB; 74120; -.
DR Antibodypedia; 42028; 33 antibodies from 16 providers.
DR DNASU; 497661; -.
DR Ensembl; ENST00000318240.8; ENSP00000323199.3; ENSG00000177576.12.
DR Ensembl; ENST00000582392.2; ENSP00000462538.1; ENSG00000177576.12.
DR Ensembl; ENST00000613385.4; ENSP00000480941.1; ENSG00000177576.12.
DR GeneID; 497661; -.
DR KEGG; hsa:497661; -.
DR MANE-Select; ENST00000318240.8; ENSP00000323199.3; NM_001035005.4; NP_001030177.1.
DR UCSC; uc002ldk.3; human.
DR CTD; 497661; -.
DR GeneCards; C18orf32; -.
DR HGNC; HGNC:31690; C18orf32.
DR HPA; ENSG00000177576; Low tissue specificity.
DR neXtProt; NX_Q8TCD1; -.
DR PharmGKB; PA162378602; -.
DR VEuPathDB; HostDB:ENSG00000177576; -.
DR GeneTree; ENSGT00390000018741; -.
DR HOGENOM; CLU_191635_0_0_1; -.
DR InParanoid; Q8TCD1; -.
DR OMA; KVDCKGT; -.
DR PhylomeDB; Q8TCD1; -.
DR TreeFam; TF324662; -.
DR PathwayCommons; Q8TCD1; -.
DR SignaLink; Q8TCD1; -.
DR BioGRID-ORCS; 497661; 18 hits in 995 CRISPR screens.
DR GenomeRNAi; 497661; -.
DR Pharos; Q8TCD1; Tdark.
DR PRO; PR:Q8TCD1; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q8TCD1; protein.
DR Bgee; ENSG00000177576; Expressed in monocyte and 97 other tissues.
DR Genevisible; Q8TCD1; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005811; C:lipid droplet; IDA:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; HMP:UniProtKB.
DR InterPro; IPR026776; UPF0729.
DR PANTHER; PTHR13456; PTHR13456; 1.
DR Pfam; PF14975; DUF4512; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Lipid droplet; Reference proteome.
FT CHAIN 1..76
FT /note="UPF0729 protein C18orf32"
FT /id="PRO_0000321908"
FT REGION 1..37
FT /note="Necessary for its localzation to the endoplasmic
FT reticulum and lipid droplets"
FT REGION 46..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 37
FT /note="P -> H (in dbSNP:rs11537626)"
FT /id="VAR_039374"
SQ SEQUENCE 76 AA; 8669 MW; 649F9A02249FAD5E CRC64;
MVCIPCIVIP VLLWIYKKFL EPYIYPLVSP FVSRIWPKKA IQESNDTNKG KVNFKGADMN
GLPTKGPTEI CDKKKD
