CR032_MOUSE
ID CR032_MOUSE Reviewed; 72 AA.
AC Q91WE4; Q3V3U8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=UPF0729 protein C18orf32 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Medulla oblongata, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May activate the NF-kappa-B signaling pathway.
CC {ECO:0000250|UniProtKB:Q8TCD1}.
CC -!- SUBUNIT: Interacts with DERL1 and AMFR. {ECO:0000250|UniProtKB:Q8TCD1}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q8TCD1}. Lipid droplet
CC {ECO:0000250|UniProtKB:Q8TCD1}.
CC -!- PTM: Undergoes ER-associated degradation (ERAD).
CC {ECO:0000250|UniProtKB:Q8TCD1}.
CC -!- SIMILARITY: Belongs to the UPF0729 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK031999; BAE20478.1; -; mRNA.
DR EMBL; AK077642; BAC36920.1; -; mRNA.
DR EMBL; AK131658; BAE20746.1; -; mRNA.
DR EMBL; BC016084; AAH16084.1; -; mRNA.
DR EMBL; BC027819; AAH27819.1; -; mRNA.
DR EMBL; BC031181; AAH31181.1; -; mRNA.
DR CCDS; CCDS37859.1; -.
DR RefSeq; NP_001001181.1; NM_001001181.3.
DR RefSeq; XP_006526143.1; XM_006526080.1.
DR RefSeq; XP_006526144.1; XM_006526081.3.
DR AlphaFoldDB; Q91WE4; -.
DR STRING; 10090.ENSMUSP00000040450; -.
DR iPTMnet; Q91WE4; -.
DR PhosphoSitePlus; Q91WE4; -.
DR SwissPalm; Q91WE4; -.
DR EPD; Q91WE4; -.
DR MaxQB; Q91WE4; -.
DR PaxDb; Q91WE4; -.
DR PeptideAtlas; Q91WE4; -.
DR PRIDE; Q91WE4; -.
DR TopDownProteomics; Q91WE4; -.
DR Antibodypedia; 42028; 33 antibodies from 16 providers.
DR Ensembl; ENSMUST00000040284; ENSMUSP00000040450; ENSMUSG00000036299.
DR Ensembl; ENSMUST00000236421; ENSMUSP00000157657; ENSMUSG00000036299.
DR Ensembl; ENSMUST00000237263; ENSMUSP00000158256; ENSMUSG00000036299.
DR GeneID; 407819; -.
DR KEGG; mmu:407819; -.
DR UCSC; uc008fpx.1; mouse.
DR MGI; MGI:3039614; BC031181.
DR VEuPathDB; HostDB:ENSMUSG00000036299; -.
DR eggNOG; ENOG502S738; Eukaryota.
DR GeneTree; ENSGT00390000018741; -.
DR HOGENOM; CLU_191635_0_0_1; -.
DR InParanoid; Q91WE4; -.
DR OMA; KVDCKGT; -.
DR OrthoDB; 1627271at2759; -.
DR PhylomeDB; Q91WE4; -.
DR TreeFam; TF324662; -.
DR BioGRID-ORCS; 407819; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q91WE4; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q91WE4; protein.
DR Bgee; ENSMUSG00000036299; Expressed in facial nucleus and 253 other tissues.
DR Genevisible; Q91WE4; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005811; C:lipid droplet; ISS:UniProtKB.
DR InterPro; IPR026776; UPF0729.
DR PANTHER; PTHR13456; PTHR13456; 1.
DR Pfam; PF14975; DUF4512; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Lipid droplet; Reference proteome.
FT CHAIN 1..72
FT /note="UPF0729 protein C18orf32 homolog"
FT /id="PRO_0000321909"
FT REGION 1..33
FT /note="Necessary for its localzation to the endoplasmic
FT reticulum and lipid droplets"
FT /evidence="ECO:0000250|UniProtKB:Q8TCD1"
FT REGION 36..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 72 AA; 8036 MW; FCCD9489F5FD47A0 CRC64;
MVCIPCIVIP VLLWIFKKFL EPYIYPVVSR IWPKKAVQQS GDKNMSKVDC KGAGTNGLPT
KGPTEVSDKK KD
