ID   CR063_HUMAN             Reviewed;         685 AA.
AC   Q68DL7; A6NME8;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Uncharacterized protein C18orf63;
GN   Name=C18orf63;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
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DR   EMBL; CR749350; CAH18203.1; -; mRNA.
DR   EMBL; AC090398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS54189.1; -.
DR   RefSeq; NP_001167594.1; NM_001174123.1.
DR   AlphaFoldDB; Q68DL7; -.
DR   BioGRID; 569262; 3.
DR   IntAct; Q68DL7; 5.
DR   MINT; Q68DL7; -.
DR   STRING; 9606.ENSP00000464330; -.
DR   iPTMnet; Q68DL7; -.
DR   PhosphoSitePlus; Q68DL7; -.
DR   BioMuta; C18orf63; -.
DR   DMDM; 205831170; -.
DR   MassIVE; Q68DL7; -.
DR   MaxQB; Q68DL7; -.
DR   PaxDb; Q68DL7; -.
DR   PeptideAtlas; Q68DL7; -.
DR   PRIDE; Q68DL7; -.
DR   ProteomicsDB; 66091; -.
DR   Antibodypedia; 49131; 2 antibodies from 2 providers.
DR   DNASU; 644041; -.
DR   Ensembl; ENST00000579455.2; ENSP00000464330.2; ENSG00000206043.7.
DR   GeneID; 644041; -.
DR   KEGG; hsa:644041; -.
DR   MANE-Select; ENST00000579455.2; ENSP00000464330.2; NM_001174123.2; NP_001167594.1.
DR   UCSC; uc002llj.4; human.
DR   CTD; 644041; -.
DR   GeneCards; C18orf63; -.
DR   HGNC; HGNC:40037; C18orf63.
DR   HPA; ENSG00000206043; Tissue enriched (testis).
DR   neXtProt; NX_Q68DL7; -.
DR   OpenTargets; ENSG00000206043; -.
DR   VEuPathDB; HostDB:ENSG00000206043; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   GeneTree; ENSGT00390000007627; -.
DR   HOGENOM; CLU_018345_0_0_1; -.
DR   InParanoid; Q68DL7; -.
DR   OMA; HWDALYG; -.
DR   OrthoDB; 1388892at2759; -.
DR   PhylomeDB; Q68DL7; -.
DR   TreeFam; TF342752; -.
DR   PathwayCommons; Q68DL7; -.
DR   SignaLink; Q68DL7; -.
DR   BioGRID-ORCS; 644041; 9 hits in 1034 CRISPR screens.
DR   GenomeRNAi; 644041; -.
DR   Pharos; Q68DL7; Tdark.
DR   PRO; PR:Q68DL7; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q68DL7; protein.
DR   Bgee; ENSG00000206043; Expressed in testis and 4 other tissues.
DR   InterPro; IPR031643; DUF4708.
DR   PANTHER; PTHR28495; PTHR28495; 1.
DR   Pfam; PF15813; DUF4708; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..685
FT                   /note="Uncharacterized protein C18orf63"
FT                   /id="PRO_0000348945"
FT   REGION          502..538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          635..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..656
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        548
FT                   /note="F -> Y (in Ref. 1; CAH18203)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        676
FT                   /note="L -> P (in Ref. 1; CAH18203)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   685 AA;  77230 MW;  D78B9E6B3E5F3D05 CRC64;
     MNDSRQQSLF FITLPDLNKL CAVRIILSNK VADTEIRTIQ MKMCRQLLFL HQDILTSPVS
     GILNQIWVVM AIPFYKARKL NAYVEKYGAK MEAPQRVIPV ILQNCLSYSF MARLAPAWNR
     TGHLLIQGRD FLSQMGKQSA VVLNINVTET QVCLSIEACT IRLPAPELKE FEISQSIIKD
     FHANKHAVIE RHSILSNWCY VLPSMKMGQI INIFHAIPAA CPFHSYGDFQ RHWDALYGYK
     LPGDCGKIKI YCNIYFKMLG ERTFTYPLSC IRSQPMQFFP RVDSEVVLKS FLSDLKSKLP
     HICGFPIKMT SKPCYYTQEL TKPNIQEHKV KPPNLTTKKM LRASLTQATS RKPACAQSLL
     PCSVAVDHKV ELSVSQPTSG IFSALHLQPE SVQGRKKSLS IRAPQVHSEV LMPNRGNTQV
     QHTNLSSQSN ITPKFVPVFK NRLLQMNKNT SVLGSPKRKQ HDVTQSKLFS LKTSMIQHDK
     LNLGPAIKNR YSSNIQMQAA NNLNQENSRP LQEKNTESSE NMTKFPSSRG KSTVSLNKNK
     QLSNSAVFVV SNNNLGVVKS AVDFQMKGKE NLTGKGITQI LGKSHGSLKL KRQPHIFESD
     GETEDPRLLQ QQSENQAKEV GTSDHRLIVS KIAHRSKRKL CPESSKTSKK HHSDTVHYGQ
     SSSSKKQILD SDKSKLKKSL IIHNA