ID   CR110_RANSP             Reviewed;          25 AA.
AC   P82104;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Caerin-1.10;
OS   Ranoidea splendida (Magnificent tree frog) (Litoria splendida).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX   NCBI_TaxID=30345;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-25, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=10601876; DOI=10.1046/j.1432-1327.2000.01010.x;
RA   Wabnitz P.A., Bowie J.H., Tyler M.J., Wallace J.C., Smith B.P.;
RT   "Differences in the skin peptides of the male and female Australian tree
RT   frog Litoria splendida. The discovery of the aquatic male sex pheromone
RT   splendipherin, together with Phe8 caerulein and a new antibiotic peptide
RT   caerin 1.10.";
RL   Eur. J. Biochem. 267:269-275(2000).
CC   -!- FUNCTION: Antibacterial peptide with wide spectrum of activity. Active
CC       against L.lactis, L.innocua, M.luteus, S.uberis and less against
CC       P.multocida and S.epidermidis. {ECO:0000269|PubMed:10601876}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- MASS SPECTROMETRY: Mass=2573; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:10601876};
CC   -!- MISCELLANEOUS: Caerin-1.10 is not present in the glandular secretion of
CC       female L.spendida.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Caerin subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P82104; -.
DR   SMR; P82104; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR010000; Caerin_1.
DR   Pfam; PF07440; Caerin_1; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Caerin-1.10"
FT                   /id="PRO_0000043741"
FT   MOD_RES         25
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:10601876"
SQ   SEQUENCE   25 AA;  2576 MW;  D8A77460BB0EBE00 CRC64;
     GLLSVLGSVA KHVLPHVVPV IAEKL