ID   CR1BB_BACTU             Reviewed;        1229 AA.
AC   Q45739;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Pesticidal crystal protein Cry1Bb;
DE   AltName: Full=140 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIB(b);
GN   Name=cry1Bb; Synonyms=cryET5, cryIB(b);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-21110 / EG5847;
RA   Donovan W.P., Tan Y., Jany C.S., Gonzalez J.M. Jr.;
RT   "Bacillus thuringiensis cryet4 and cryet5 toxin genes and proteins toxic to
RT   lepidopteran insects.";
RL   Patent number US5322687, 21-JUN-1994.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of many lepidopteran larvae.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; L32020; AAA22344.1; -; Genomic_DNA.
DR   RefSeq; WP_000203375.1; NZ_CP014853.1.
DR   AlphaFoldDB; Q45739; -.
DR   SMR; Q45739; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1229
FT                   /note="Pesticidal crystal protein Cry1Bb"
FT                   /id="PRO_0000174031"
SQ   SEQUENCE   1229 AA;  139771 MW;  A4C949DB675C3269 CRC64;
     MTSNRKNENE IINALSIPTV SNPSTQMNLS PDARIEDSLC VAEVNNIDPF VSASTVQTGI
     NIAGRILGVL GVPFAGQLAS FYSFLVGELW PSGRDPWEIF LEHVEQLIRQ QVTENTRNTA
     IARLEGLGRG YRSYQQALET WLDNRNDARS RSIILERYVA LELDITTAIP LFRIRNEEVP
     LLMVYAQAAN LHLLLLRDAS LFGSEWGMAS SDVNQYYQEQ IRYTEEYSNH CVQWYNTGLN
     NLRGTNAESW LRYNQFRRDL TLGVLDLVAL FPSYDTRTYP INTSAQLTRE IYTDPIGRTN
     APSGFASTNW FNNNAPSFSA IEAAIFRPPH LLDFPEQLTI YSASSRWSST QHMNYWVGHR
     LNFRPIGGTL NTSTQGLTNN TSINPVTLQF TSRDVYRTES NAGTNILFTT PVNGVPWARF
     NFINPQNIYE RGATTYSQPY QGVGIQLFDS ETELPPETTE RPNYESYSHR LSHIGLIIGN
     TLRAPVYSWT HRSADRTNTI GPNRITQIPL VKALNLHSGV TVVGGPGFTG GDILRRTNTG
     TFGDIRLNIN VPLSQRYRVR IRYASTTDLQ FFTRINGTTV NIGNFSRTMN RGDNLEYRSF
     RTAGFSTPFN FLNAQSTFTL GAQSFSNQEV YIDRVEFVPA EVTFEAEYDL ERAQKAVNAL
     FTSTNPRRLK TDVTDYHIDQ VSNMVACLSD EFCLDEKREL FEKVKYAKRL SDERNLLQDP
     NFTFISGQLS FASIDGQSNF PSINELSEHG WWGSANVTIQ EGNDVFKENY VTLPGTFNEC
     YPNYLYQKIG ESELKAYTRY QLRGYIEDSQ DLEIYLIRYN AKHETLDVPG TDSLWPLSVE
     SPIGRCGEPN RCAPHFEWNP DLDCSCRDGE RCAHHSHHFT LDIDVGCTDL HENLGVWVVF
     KIKTQEGYAR LGNLEFIEEK PLIGEALSRV KRAEKKWRDK REKLQLETKR VYTEAKEAVD
     ALFVDSQYDQ LQADTNIGMI HAADKLVHRI REAYLSELPV IPGVNAEIFE ELEGHIITAM
     SLYDARNVVK NGDFNNGLTC WNVKGHVDVQ QSHHRSDLVI PEWEAEVSQA VRVCPGRGYI
     LRVTAYKEGY GEGCVTIHEI ENNTDELKFK NCEEEEVYPT DTGTCNDYTA HQGTAACNSR
     NAGYEDAYEV DTTASVNYKP TYEEETYTDV RRDNHCEYDR GYVNYPPVPA GYVTKELEYF
     PETDTVWIEI GETEGKFIVD SVELLLMEE