CR1BC_BACTM
ID CR1BC_BACTM Reviewed; 1233 AA.
AC Q45774;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Pesticidal crystal protein Cry1Bc;
DE AltName: Full=140 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryIB(c);
GN Name=cry1Bc; Synonyms=cryIB(c), cryIBc;
OS Bacillus thuringiensis subsp. morrisoni.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1441;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Bishop A.H., Bone E.J., Ellar D.J.;
RT "Cloning of novel Bacillus thuringiensis delta-endotoxin.";
RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of insects.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC and is accumulated both as an inclusion and as part of the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR EMBL; Z46442; CAA86568.1; -; Genomic_DNA.
DR AlphaFoldDB; Q45774; -.
DR SMR; Q45774; -.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR InterPro; IPR041587; Cry_V.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR038979; Pest_crys.
DR InterPro; IPR005638; Pest_crys_C.
DR InterPro; IPR005639; Pest_crys_N.
DR InterPro; IPR036716; Pest_crys_N_sf.
DR InterPro; IPR001178; Pest_cryst_cen_dom.
DR InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR PANTHER; PTHR37003; PTHR37003; 1.
DR Pfam; PF17997; Cry1Ac_D5; 1.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Sporulation; Toxin; Virulence.
FT CHAIN 1..1233
FT /note="Pesticidal crystal protein Cry1Bc"
FT /id="PRO_0000174032"
SQ SEQUENCE 1233 AA; 140452 MW; 7318382413529F21 CRC64;
MTSNRKNENE IINALSIPTV SNPSTQMNLS PDARIEDSLC VAEVNNIDPF VSASTVQTGI
NIAGRILGVL GVPFAGQLAS FYSFLVGELW PSGRDPWEIF LEHVEQLIRQ QVTENTRNTA
IARLEGLGRG YRSYQQALET WLDNRNDARS RSIILERYVA LELDITTAIP LFRIRNEEVP
LLMVYAQAAN LHLLLLRDAS LFGSEWGMAS SDVNQYYQEQ IRYTEEYSNH CVQWYNTGLN
NLRGTNAESW LRYNQFRRDL TLGVLDLVAL FPSYDTRTYP INTSAQLTRE IYTDPIGRTN
APSGFASTNW FNNNAPSFSA IEAAIFRPPH LLDFPEQLTI YSASSRWSST QHMNYWVGHR
LNFRPIGGTL NTSTQGLTNN TSINPVTLQF TSRDVYRTES NAGTNILFTT PVNGVPWARF
NFINPQNIYE RGATTYSQPY QGVGIQLFDS ETELPPETTE RPNYESYSHR LSHIGLIIGN
TLRAPVYSWT HRSADRTNTI GPNRITQIPL VKALNLHSGV TVVGGPGFTG GDILRRTNTG
TFGDIRLNIN VPLSQRYRVR IRYASTTDLQ FFTRINGTTV NIGNFSRTMN RGDNLEYRSF
RTAGFSTPFN FLNAQSTFTL GAQSFSNQEV YIDRVEFVPA EVTFEAEYDL ERAQKAVNAL
FTSTNPRRLK TDVTDYHIDQ VSNMVACLSD EFCLDEKREL FEKVKYAKRL SDERNLLQDP
NFTFISGQLS FASIDGQSNF PSINELSEHG WWGSANVTIQ EGNDVFKENY VTLPGTFNEC
YPNYLYQKIG ESELKAYTRY QLRGYIENSQ DLEIYLIRYN AKHEAINVPG TESIWSISAE
STIGKCTEPN RCAPHYEWNP DLDCSCRDGE KCAHHSHHST LDIDVGCTDL HENLGVWLIF
KIKTQDGHAR LGNLEYLEEK PLLGEALRRV KRTEKKWRDK REKLHLETKR VYTEAKESVD
ALFVDSQYDR LQANSNIGMI HAADKLVHSI REAYLSELPV IRGVNADIFE ELEGHILTAF
SLYDARNAVK NGDFNNGLTC WNVKGHVDVQ QSHHRFDLVV PEWKAEVSQA VRVCPGCGYI
LRVTAYKEGY GEGCVTIHEI EENTDELNFK NRVEEEIYPP DTGTCKYYTE NQGTRTCGNE
CGSRNEGYDN AYEINAKSSL EYRPTYEEET YTDVRRENHC EYARGYINYS PVPAGYVTKE
LEYFPETDTV WIEIGETEGK FIVDSVELLL MEE