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CR1BC_BACTM
ID   CR1BC_BACTM             Reviewed;        1233 AA.
AC   Q45774;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Pesticidal crystal protein Cry1Bc;
DE   AltName: Full=140 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIB(c);
GN   Name=cry1Bc; Synonyms=cryIB(c), cryIBc;
OS   Bacillus thuringiensis subsp. morrisoni.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bishop A.H., Bone E.J., Ellar D.J.;
RT   "Cloning of novel Bacillus thuringiensis delta-endotoxin.";
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; Z46442; CAA86568.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q45774; -.
DR   SMR; Q45774; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1233
FT                   /note="Pesticidal crystal protein Cry1Bc"
FT                   /id="PRO_0000174032"
SQ   SEQUENCE   1233 AA;  140452 MW;  7318382413529F21 CRC64;
     MTSNRKNENE IINALSIPTV SNPSTQMNLS PDARIEDSLC VAEVNNIDPF VSASTVQTGI
     NIAGRILGVL GVPFAGQLAS FYSFLVGELW PSGRDPWEIF LEHVEQLIRQ QVTENTRNTA
     IARLEGLGRG YRSYQQALET WLDNRNDARS RSIILERYVA LELDITTAIP LFRIRNEEVP
     LLMVYAQAAN LHLLLLRDAS LFGSEWGMAS SDVNQYYQEQ IRYTEEYSNH CVQWYNTGLN
     NLRGTNAESW LRYNQFRRDL TLGVLDLVAL FPSYDTRTYP INTSAQLTRE IYTDPIGRTN
     APSGFASTNW FNNNAPSFSA IEAAIFRPPH LLDFPEQLTI YSASSRWSST QHMNYWVGHR
     LNFRPIGGTL NTSTQGLTNN TSINPVTLQF TSRDVYRTES NAGTNILFTT PVNGVPWARF
     NFINPQNIYE RGATTYSQPY QGVGIQLFDS ETELPPETTE RPNYESYSHR LSHIGLIIGN
     TLRAPVYSWT HRSADRTNTI GPNRITQIPL VKALNLHSGV TVVGGPGFTG GDILRRTNTG
     TFGDIRLNIN VPLSQRYRVR IRYASTTDLQ FFTRINGTTV NIGNFSRTMN RGDNLEYRSF
     RTAGFSTPFN FLNAQSTFTL GAQSFSNQEV YIDRVEFVPA EVTFEAEYDL ERAQKAVNAL
     FTSTNPRRLK TDVTDYHIDQ VSNMVACLSD EFCLDEKREL FEKVKYAKRL SDERNLLQDP
     NFTFISGQLS FASIDGQSNF PSINELSEHG WWGSANVTIQ EGNDVFKENY VTLPGTFNEC
     YPNYLYQKIG ESELKAYTRY QLRGYIENSQ DLEIYLIRYN AKHEAINVPG TESIWSISAE
     STIGKCTEPN RCAPHYEWNP DLDCSCRDGE KCAHHSHHST LDIDVGCTDL HENLGVWLIF
     KIKTQDGHAR LGNLEYLEEK PLLGEALRRV KRTEKKWRDK REKLHLETKR VYTEAKESVD
     ALFVDSQYDR LQANSNIGMI HAADKLVHSI REAYLSELPV IRGVNADIFE ELEGHILTAF
     SLYDARNAVK NGDFNNGLTC WNVKGHVDVQ QSHHRFDLVV PEWKAEVSQA VRVCPGCGYI
     LRVTAYKEGY GEGCVTIHEI EENTDELNFK NRVEEEIYPP DTGTCKYYTE NQGTRTCGNE
     CGSRNEGYDN AYEINAKSSL EYRPTYEEET YTDVRRENHC EYARGYINYS PVPAGYVTKE
     LEYFPETDTV WIEIGETEGK FIVDSVELLL MEE
 
 
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