ID   CR1BD_BACTZ             Reviewed;        1231 AA.
AC   Q9ZAZ5;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Pesticidal crystal protein Cry1Bd;
DE   AltName: Full=140 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIB(d);
GN   Name=cry1Bd; Synonyms=cryE1, cryIB(d), cryLA1;
OS   Bacillus thuringiensis subsp. wuhanensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=52024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HD-525;
RX   PubMed=10688690; DOI=10.1007/s002849910046;
RA   Kuo W.-S., Lin J.-H., Tzeng C.-C., Kao S.-S., Chak K.-F.;
RT   "Cloning of two new cry genes from Bacillus thuringiensis subsp. wuhanensis
RT   strain.";
RL   Curr. Microbiol. 40:227-232(2000).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of lepidopteran larvae. Toxic to Plutella xylostella.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; U70726; AAD10292.1; -; Genomic_DNA.
DR   RefSeq; WP_033698198.1; NZ_NFEE01000106.1.
DR   AlphaFoldDB; Q9ZAZ5; -.
DR   SMR; Q9ZAZ5; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1231
FT                   /note="Pesticidal crystal protein Cry1Bd"
FT                   /id="PRO_0000174033"
SQ   SEQUENCE   1231 AA;  139655 MW;  129A0371CDDBEE52 CRC64;
     MTSNRKNENE IINALSIPAV SNHSAQMDLS LDARIEDSLC IAEGNNINPL VSASTVQTGI
     NIAGRILGVL GVPFAGQLAS FYSFLVGELW PSGRDPWEIF LEHVEQLIRQ QVTENTRNTA
     IARLEGLGRG YRSYQQALET WLDNRNDARS RSIILERYVA LELDITTAIP LFRIRNEEVP
     LLMVYAQAAN LHLLLLRDAS LFGSEWGMAS SDVNQYYQEQ IRYTEEYSNH CVQWYNTGLN
     NLRGTNAESW LRYNQFRRDL TLGVLDLVAL FPSYDTRTYP INTSAQLTRE IYTDPIGRTN
     APSGFASTNW FNNNAPSFSA IEAAIFRPPH LLDFPEQLTI YSASSRWSST QHMNYWVGHR
     LNFRPIGGTL NTSTQGLTNN TSINPVTLQF TSRDVYRTES NAGTNILFTT PVNGVPWARF
     NFINPQNIYE RGATTYSQPY QGVGIQLFDS ETELPPETTE RPNYESYSHR LSHIGLIIGN
     TLRAPVYSWT HRSADRTNTI GPNRITQIPA VKGRFLFNGS VISGPGFTGG DVVRLNRNNG
     NIQNRGYIEV PIQFTSTSTR YRVRVRYASV TSIELNVNLG NSSIFTNTLP ATAASLDNLQ
     SGDFGYVEIN NAFTSATGNI VGARNFSANA EVIIDRFEFI PVTATFEAEY DLERAQKAVN
     ALFTSTNPRR LKTDVTDYHI DQVSNMVACL SDEFCLDEKR ELFEKVKYAK RLSDERNLLQ
     DPNFTFISGQ LSFASIDGQS NFTSINELSE HGWWGSENVT IQEGNDVFKE NYVTLPGTFN
     ECYPNYLYQK IGESELKAYT RYQLRGYIED SQDLEIYLIR YNAKHETLDV PGTDSLWPLS
     VKSPIGRCGE PNRCAPHFEW NPDLDCSCRD GERCAHHSHH FTLDIDVGCT DLHENLGVWV
     VFKIKTQEGY ARLGNLEFIE EKPLIGEALS RVKRAEKKWR DKREKLQLET KRVYTEAKET
     VDALFVDSHY NRLQADTNIG MIHAADRLVH RIHEAYLPEL PFIPGINAVI FEELENRIST
     AFSLYDARNV IKNGDFNNGL SCWNVKGHVD VQQSHHRSDL VIPEWEAEVS QAVRVCPGRG
     YILRVTAYKE GYGEGCVTIH EIENNTDELK FKNCEEEEVY PTDTGTCNDY TAHQGTAACN
     SRNAGYEDAY EVDTTASVNY KPTYEEETYT DVRRDNHCEY DRGYVNYPPV PAGYVTKELE
     YFPETDTVWI EIGETEGKFI VDSVELLLME E