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CR1CA_BACTA
ID   CR1CA_BACTA             Reviewed;        1189 AA.
AC   P0A376; P05518; P10327; Q03742; Q45725;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Pesticidal crystal protein Cry1Ca;
DE   AltName: Full=134 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIC(a);
GN   Name=cry1Ca; Synonyms=cryIC, cryIC(a);
OS   Bacillus thuringiensis subsp. aizawai.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1433;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-18484 / PS81I;
RA   Payne J.M., Sick A.J.;
RT   "Bacillus thuringiensis isolate active against lepidopteran pests, and
RT   genes encoding novel lepidopteran-active toxins.";
RL   Patent number US5246852, 21-SEP-1993.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-823.
RC   STRAIN=7-29;
RX   PubMed=2548060; DOI=10.1111/j.1365-2958.1989.tb01812.x;
RA   Sanchis V., Lerechus D., Menou M., Chaufaux J., Guo S., Lecadet M.-M.;
RT   "Nucleotide sequence and analysis of the N-terminal coding region of the
RT   Spodoptera-active delta-endotoxin gene of Bacillus thuringiensis aizawai
RT   7.29.";
RL   Mol. Microbiol. 3:229-238(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-756.
RC   STRAIN=7-29 / K26-21;
RA   Strizhov N.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of many lepidopteran larvae including Spodoptera
CC       species.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; M73251; AAA22343.1; -; Genomic_DNA.
DR   EMBL; X13620; CAA31951.1; -; Genomic_DNA.
DR   EMBL; X96682; CAA65457.1; -; Genomic_DNA.
DR   PIR; S04181; S04181.
DR   AlphaFoldDB; P0A376; -.
DR   SMR; P0A376; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1189
FT                   /note="Pesticidal crystal protein Cry1Ca"
FT                   /id="PRO_0000174035"
FT   CONFLICT        366
FT                   /note="N -> I (in Ref. 2; CAA31951)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        376..380
FT                   /note="WPAPP -> CQRHH (in Ref. 2; CAA31951)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        386
FT                   /note="V -> G (in Ref. 2; CAA31951)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        405
FT                   /note="T -> Q (in Ref. 1; AAA22343)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        775
FT                   /note="R -> A (in Ref. 2; CAA31951)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1189 AA;  134786 MW;  E8523ACE4742629C CRC64;
     MEENNQNQCI PYNCLSNPEE VLLDGERIST GNSSIDISLS LVQFLVSNFV PGGGFLVGLI
     DFVWGIVGPS QWDAFLVQIE QLINERIAEF ARNAAIANLE GLGNNFNIYV EAFKEWEEDP
     NNPATRTRVI DRFRILDGLL ERDIPSFRIS GFEVPLLSVY AQAANLHLAI LRDSVIFGER
     WGLTTINVNE NYNRLIRHID EYADHCANTY NRGLNNLPKS TYQDWITYNR LRRDLTLTVL
     DIAAFFPNYD NRRYPIQPVG QLTREVYTDP LINFNPQLQS VAQLPTFNVM ESSAIRNPHL
     FDILNNLTIF TDWFSVGRNF YWGGHRVISS LIGGGNITSP IYGREANQEP PRSFTFNGPV
     FRTLSNPTLR LLQQPWPAPP FNLRGVEGVE FSTPTNSFTY RGRGTVDSLT ELPPEDNSVP
     PREGYSHRLC HATFVQRSGT PFLTTGVVFS WTHRSATLTN TIDPERINQI PLVKGFRVWG
     GTSVITGPGF TGGDILRRNT FGDFVSLQVN INSPITQRYR LRFRYASSRD ARVIVLTGAA
     STGVGGQVSV NMPLQKTMEI GENLTSRTFR YTDFSNPFSF RANPDIIGIS EQPLFGAGSI
     SSGELYIDKI EIILADATFE AESDLERAQK AVNALFTSSN QIGLKTDVTD YHIDQVSNLV
     DCLSDEFCLD EKRELSEKVK HAKRLSDERN LLQDPNFRGI NRQPDRGWRG STDITIQGGD
     DVFKENYVTL PGTVDECYPT YLYQKIDESK LKAYTRYELR GYIEDSQDLE IYLIRYNAKH
     EIVNVPGTGS LWPLSAQSPI GKCGEPNRCA PHLEWNPDLD CSCRDGEKCA HHSHHFTLDI
     DVGCTDLNED LGLWVIFKIK TQDNHARLGN LEFLEEKPLL GEALARVKRA EKKWRDKREK
     LQLETNIVYK EAKESVDALF VNSQYDRLQV NTNIAMIHAA DKRVHRIREA YLPELSVIPG
     VNAAIFEELE GRIFTAYSLY DARNVIKNGD FNNGLLCWNV KGHVDVEEQN NHRSVLVIPE
     WEAEVSQEVR VCPGRGYILR VTAYKEGYGE GCVTIHEIED NTDELKFSNC VEEEVYPNNT
     VTCNNYTGTQ EEYEGTYTSR NQGYDEAYGN NPSVPADYAS VYEEKSYTDG RRENPCESNR
     GYGDYTPLPA GYVTKDLEYF PETDKVWIEI GETEGTFIVD SVELLLMEE
 
 
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