ID   CR1CA_BACTE             Reviewed;        1189 AA.
AC   P0A375; P05518; P10327; Q03742; Q45725;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Pesticidal crystal protein Cry1Ca;
DE   AltName: Full=134 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryIC(a);
GN   Name=cry1Ca; Synonyms=cryIC, cryIC(a);
OS   Bacillus thuringiensis subsp. entomocidus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1436;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=60.5;
RX   PubMed=3399402; DOI=10.1093/nar/16.13.6240;
RA   Honee G., van der Salm T.P.M., Visser B.;
RT   "Nucleotide sequence of crystal protein gene isolated from B. thuringiensis
RT   subspecies entomocidus 60.5 coding for a toxin highly active against
RT   Spodoptera species.";
RL   Nucleic Acids Res. 16:6240-6240(1988).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of many lepidopteran larvae including Spodoptera
CC       species.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; X07518; CAA30396.1; -; Genomic_DNA.
DR   PIR; S00944; S00944.
DR   AlphaFoldDB; P0A375; -.
DR   SMR; P0A375; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..1189
FT                   /note="Pesticidal crystal protein Cry1Ca"
FT                   /id="PRO_0000174036"
SQ   SEQUENCE   1189 AA;  134837 MW;  A68C6F986DE9A162 CRC64;
     MEENNQNQCI PYNCLSNPEE VLLDGERIST GNSSIDISLS LVQFLVSNFV PGGGFLVGLI
     DFVWGIVGPS QWDAFLVQIE QLINERIAEF ARNAAIANLE GLGNNFNIYV EAFKEWEEDP
     NNPETRTRVI DRFRILDGLL ERDIPSFRIS GFEVPLLSVY AQAANLHLAI LRDSVIFGER
     WGLTTINVNE NYNRLIRHID EYADHCANTY NRGLNNLPKS TYQDWITYNR LRRDLTLTVL
     DIAAFFPNYD NRRYPIQPVG QLTREVYTDP LINFNPQLQS VAQLPTFNVM ESSRIRNPHL
     FDILNNLTIF TDWFSVGRNF YWGGHRVISS LIGGGNITSP IYGREANQEP PRSFTFNGPV
     FRTLSNPTLR LLQQPWPAPP FNLRGVEGVE FSTPTNSFTY RGRGTVDSLT ELPPEDNSVP
     PREGYSHRLC HATFVQRSGT PFLTTGVVFS WTDRSATLTN TIDPERINQI PLVKGFRVWG
     GTSVITGPGF TGGDILRRNT FGDFVSLQVN INSPITQRYR LRFRYASSRD ARVIVLTGAA
     STGVGGQVSV NMPLQKTMEI GENLTSRTFR YTDFSNPFSF RANPDIIGIS EQPLFGAGSI
     SSGELYIDKI EIILADATFE AESDLERAQK AVNALFTSSN QIGLKTDVTD YHIDQVSNLV
     DCLSDEFCLD EKRELSEKVK HAKRLSDERN LLQDPNFRGI NRQPDRGWRG STDITIQGGD
     DVFKENYVTL PGTVDECYPT YLYQKIDESK LKAYTRYELR GYIEDSQDLE IYLIRYNAKH
     EIVNVPGTGS LWPLSAQSPI GKCGEPNRCA PHLEWNPDLD CSCRDGEKCA HHSHHFTLDI
     DVGCTDLNED LGVWVIFKIK TQDGHARLGN LEFLEEKPLL GEALARVKRA EKKWRDKREK
     LQLETNIVYK EAKESVDALF VNSQYDRLQV DTNIAMIHAA DKRVHRIREA YLPELSVIPG
     VNAAIFEELE GRIFTAYSLY DARNVIKNGD FNNGLLCWNV KGHVDVEEQN NHRSVLVIPE
     WEAEVSQEVR VCPGRGYILR VTAYKEGYGE GCVTIHEIED NTDELKFSNC VEEEVYPNNT
     VTCNNYTGTQ EEYEGTYTSR NQGYDEAYGN NPSVPADYAS VYEEKSYTDG RRENPCESNR
     GYGDYTPLPA GYVTKDLEYF PETDKVWIEI GETEGTFIVD SVELLLMEE